Nowak D, Radenbach D, Magnussen H
Dtsch Med Wochenschr. 1987 Sep 4;112(36):1367-70. doi: 10.1055/s-2008-1068252.
Conversion rate to negativity of sputum culture and microscopy in 50 patients, previously untreated, with open cavernous pulmonary tuberculosis was analysed. Treatment consisted of isoniazid, rifampicin and pyrazinamide for three months, followed by administration of isoniazid and rifampicin. Conversion to a negative sputum culture had occurred after four weeks in 30% of patients, after eight weeks in 84%, and after 14 weeks in all patients. In 76% of patients the cultural conversion preceded the microscopic one. Treatment was well tolerated; only one patient had side effects requiring a short interruption of drug administration. The results confirm that this regimen is effective against pulmonary tuberculosis without significant side effects.
分析了50例初治开放性空洞型肺结核患者痰培养和显微镜检查转阴率。治疗方案为异烟肼、利福平及吡嗪酰胺联合应用3个月，随后给予异烟肼和利福平。30%的患者在4周后痰培养转阴，84%的患者在8周后转阴，所有患者在14周后转阴。76%的患者痰培养转阴先于显微镜检查转阴。治疗耐受性良好；仅1例患者出现副作用，需要短暂中断给药。结果证实该方案对肺结核有效且无明显副作用。
