Departments of Ophthalmology.
Health Sciences Research, Mayo Clinic, Rochester, MN.
J Glaucoma. 2023 Mar 1;32(3):210-220. doi: 10.1097/IJG.0000000000002136. Epub 2022 Oct 12.
Surgical and clinical success rates were similar among Ahmed FP7, and Baerveldt 250 and 350 glaucoma drainage devices at three years.
To compare rates of surgical and clinical success in patients with Ahmed FP7 (FP7), Baerveldt 250 (B250), or Baerveldt 350 (B350) glaucoma drainage devices (GDDs).
A retrospective cohort study.
A total of 157 eyes of 129 adult patients with FP7, B250, B350 GDDs, and 190 eyes of 99 medically controlled glaucoma patients were enrolled at a tertiary care institution from August 2017 through July 2019. They were followed through April 2020. The main outcome measures included surgical and clinical failure. Surgical failure was defined as intraocular pressure (IOP) outside 5-21 mm Hg, IOP reduced <20% below baseline, additional glaucoma surgery, GDD removal, or no light perception. Eyes that did not meet their goal IOP ranges or required secondary glaucoma interventions were deemed clinical failures.
A total of 43 (12.4%) FP7, 36 (10.4%) B250, 78 (22.5%) B350, and 190 (54.8%) medically treated control eyes were enrolled. By the postoperative year 3 visit, 10 (23.2%) FP7, 11 (30.6%) B250, and 32 (41.0%) B350 eyes had met a surgical failure criterion ( P =0.127). There were no significant differences in the numbers of eyes meeting their IOP target ranges ( P =0.510), and rates of secondary glaucoma surgeries ( P =0.270). Overall clinical success was attained among 83.3% FP7, 81.8% B250, and 68.0% B350 eyes ( P =0.447).
The GDD groups were similar in their rates of success, based on both the surgical and clinical success definitions.
在三年内，Ahmed FP7、Baerveldt 250 和 350 青光眼引流装置的手术和临床成功率相似。
比较 Ahmed FP7（FP7）、Baerveldt 250（B250）和 Baerveldt 350（B350）青光眼引流装置（GDD）患者的手术和临床成功率。
回顾性队列研究。
2017 年 8 月至 2019 年 7 月，在一家三级医疗机构招募了 157 只眼的 129 名成年 FP7、B250、B350 GDD 患者，以及 190 只眼的 99 名接受药物控制的青光眼患者。这些患者随访至 2020 年 4 月。主要结局指标包括手术和临床失败。手术失败定义为眼压（IOP）在 5-21mmHg 之外、IOP 降低低于基线 20%以下、需要额外的青光眼手术、GDD 移除或无光感。未达到目标眼压范围或需要二次青光眼干预的眼睛被认为是临床失败。
共纳入 43 只（12.4%）FP7、36 只（10.4%）B250、78 只（22.5%）B350 和 190 只（54.8%）接受药物治疗的对照组眼睛。在术后 3 年就诊时，10 只（23.2%）FP7、11 只（30.6%）B250 和 32 只（41.0%）B350 眼睛达到了手术失败标准（P=0.127）。达到目标眼压范围的眼睛数量没有显著差异（P=0.510），二次青光眼手术的发生率也没有显著差异（P=0.270）。FP7、B250 和 B350 组的总体临床成功率分别为 83.3%、81.8%和 68.0%（P=0.447）。
根据手术和临床成功的定义，GDD 组的成功率相似。
