需要一个村庄才能扭曲一个淋巴结。

It takes a village to skew a lymph node.

机构信息

University of Oxford, MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine and Nuffield Department of Medicine, Oxford, UK.

University of Oxford, Kennedy Institute of Rheumatology, Oxford, UK.

出版信息

Immunity. 2022 Oct 11;55(10):1751-1753. doi: 10.1016/j.immuni.2022.09.008.

DOI:10.1016/j.immuni.2022.09.008

PMID:36223721

Abstract

Unconventional T cells (UTCs) play important roles in protecting barrier tissues. In this issue of Immunity, Ataide and colleagues show an additional function for these cells: populating downstream lymph nodes and skewing their cytokine profiles. This process allows tissues to adjust the function of draining lymph nodes through imprinting UTC cytokine production, subsequently influencing the immune responses that are triggered.

摘要

非传统 T 细胞（UTCs）在保护屏障组织方面发挥着重要作用。在本期《免疫》杂志中，Ataide 及其同事展示了这些细胞的另一个功能：UTCs 填充下游淋巴结并改变其细胞因子谱。这一过程允许组织通过印记 UTC 细胞因子的产生来调整引流淋巴结的功能，进而影响所引发的免疫反应。