Biotechnology of Tropical Medicinal Plants Research Group, Universitas Airlangga, 60115 Surabaya, Indonesia.
Department of Biology, Faculty of Science and Technology, Universitas Airlangga, 60115 Surabaya, Indonesia.
Front Biosci (Landmark Ed). 2022 Sep 29;27(9):274. doi: 10.31083/j.fbl2709274.
is responsible for a wide range of medical ailments, from harmless cutaneous to life-threatening bloodstream infections. Growing cases of antifungal-drug resistance strains of become a rationale to explore and develop novel anti-candida agents. In this paper, we assessed the anti-candida activity of the methanolic extracts of various tropical medicinal plants from Myrtaceae, Poaceae, and Zingiberaceae, commonly used in Indonesia to treat fungal infections.
strain ATCC 10231 was used as a subject to assess the anti-Candida activities of plant methanolic extracts through disc diffusion assay. Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) were observed.
All plant extracts in this study showed antifungal activities against . Among them, , and var. showed the lowest MIC and MFC value of 3.8 mg/mL.
The growth inhibition of on disc diffusion assay was demonstrated by var. and , which were comparable to antifungal nystatin. Further investigation of the chemical constituents of the extracts and the cytotoxicity test is needed to further develop plant-derived anti-candida agents.
假丝酵母菌能够引发多种医学疾病，从无危害的皮肤感染到危及生命的血流感染都有可能。抗真菌药物耐药菌株不断增加，这为探索和开发新型抗真菌药物提供了合理依据。在本文中，我们评估了来自桃金娘科、禾本科和姜科的各种热带药用植物甲醇提取物对白色念珠菌的抗真菌活性，这些植物在印度尼西亚常用于治疗真菌感染。
采用纸片扩散法，以 ATCC 10231 菌株作为受试菌，评估植物甲醇提取物的抗真菌活性。观察最小抑菌浓度（MIC）和最小杀菌浓度（MFC）。
本研究中的所有植物提取物均对白色念珠菌表现出抗真菌活性。其中，桃金娘科的 和 ，禾本科的 ，姜科的 ，表现出最低的 MIC 和 MFC 值，均为 3.8mg/mL。
通过纸片扩散法证实了桃金娘科的 和 ，禾本科的 对白色念珠菌的生长抑制作用，与抗真菌药物制霉菌素相当。需要进一步研究提取物的化学成分和细胞毒性试验，以进一步开发植物来源的抗真菌药物。
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