Palacios J M, Fastbom J, Wiederhold K H, Probst A
Eur J Pharmacol. 1987 Jun 19;138(2):273-6. doi: 10.1016/0014-2999(87)90443-2.
Adenosine A1 receptors were localized in sections of human and guinea-pig kidney with quantitative receptor autoradiography and [3H]cyclohexyladenosine [( 3H]CHA) used as ligand. The binding sites had the characteristics of an A1 receptor. In the human kidney a high density of receptor sites was measured over the glomeruli. In the guinea-pig kidney the receptor sites were localized in the inner and outer medulla although a low density of binding was also seen over the glomeruli. The functional significance of the findings is discussed.
利用定量受体放射自显影技术，以[3H]环己基腺苷（[3H]CHA）作为配体，在人和豚鼠肾脏切片中定位腺苷A1受体。这些结合位点具有A1受体的特征。在人肾脏中，肾小球上检测到高密度的受体位点。在豚鼠肾脏中，受体位点定位于内髓和外髓，尽管在肾小球上也观察到低密度的结合。讨论了这些发现的功能意义。
