Dermatology and Venereology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy for Girls, Al-Azhar University, Cairo, Egypt.
Dermatol Ther. 2022 Dec;35(12):e15935. doi: 10.1111/dth.15935. Epub 2022 Oct 28.
Although being a benign lesion, Warts can affect the quality of life by causing discomfort, disfigurement, and social embarrassment besides the tendency to spread. Cutaneous wart treatment faces many challenges as the development of an antiviral drug that can eradicate the human papilloma virus (HPV) is difficult. This clinical study aimed to assess the efficacy and safety of intralesional combined furosemide and digoxin in the treatment of multiple cutaneous warts. This double blinded randomized clinical trial included 80 adult patients with multiple cutaneous warts (≥2 warts) who were randomized into two groups, Group I (40 patients) treated with intralesional combined furosemide and digoxin and Group II (40 patients) who were treated with intralesional normal saline solution as a control group, weekly till improvement or for maximum five sessions. Clinical and dermoscopic evaluation at baseline, every session, and monthly for 6 months after the last session to detect any recurrence was performed. Complete wart clearance was observed in 92.5% of patients in the intralesional combined furosemide and digoxin group (Group I) compared with 10.0% in saline group (Group II), with highly statistically significant difference (P-value = 0.000). Pain during injection in 95.0% and 45.0% of patients in Group I and Group II respectively, treatment group was superior compared to control group. Intralesional injection of combined furosemide and digoxin can be a safe and effective treatment option in multiple cutaneous warts with minimal side effects in this study.
虽然是良性病变，但疣除了有传播倾向外，还会引起不适、畸形和社交尴尬，从而影响生活质量。由于开发一种能根除人乳头瘤病毒 (HPV) 的抗病毒药物存在困难，因此皮肤疣的治疗面临诸多挑战。本临床研究旨在评估病灶内联合使用呋塞米和地高辛治疗多发性皮肤疣的疗效和安全性。这是一项双盲随机临床试验，纳入了 80 例多发性皮肤疣（≥2 个疣）的成年患者，将他们随机分为两组，第 I 组（40 例）接受病灶内联合使用呋塞米和地高辛治疗，第 II 组（40 例）接受病灶内生理盐水作为对照组治疗，每周一次，最多进行 5 次治疗。在基线、每次治疗和末次治疗后 6 个月每月进行临床和皮肤镜评估，以检测任何复发情况。病灶内联合使用呋塞米和地高辛组（第 I 组）的患者中，92.5%的患者完全清除了疣，而生理盐水组（第 II 组）的患者中，只有 10.0%的患者完全清除了疣，差异具有统计学意义（P 值=0.000）。第 I 组和第 II 组分别有 95.0%和 45.0%的患者在注射时感到疼痛，治疗组明显优于对照组。在本研究中，病灶内注射联合使用呋塞米和地高辛是一种安全有效的多发性皮肤疣治疗方法，副作用最小。
