Dermatology Department-Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ain Shams University, Cairo, Egypt.
J Cosmet Dermatol. 2021 Aug;20(8):2606-2611. doi: 10.1111/jocd.13913. Epub 2021 Jan 3.
Warts are small, benign growths caused by human papilloma virus. No treatment has yet proven 100% effective for a cure. DNA viruses rely on K + influx for replication. Both digoxin and furosemide inhibit the K + influx by interacting with cell membrane ion co-transporters. Therefore, it is hypothesized that these two compounds may be valuable in the treatment of warts.
Our aim was to evaluate the efficacy and safety of intralesional injection of a combination of digoxin and furosemide in treatment of plantar warts.
PATIENTS/METHODS: This two-armed single blinded randomized clinical trial included 40 cases with multiple plantar warts (≥3warts) divided into 2 groups (20 cases each). The first group received intralesional normal saline and the second group received intralesional combined digoxin and furosemide, one session every week for maximum 5 injection sessions.
On comparing between the 2 groups regarding response to treatment (reduction in number of warts), the first group showed no change in number of warts (82 warts before and after treatment), whereas, in the second group, the number of warts before treatment was 80 while after treatment it was 40 (50% reduction in number). There was a statistically significant difference between the two groups as regard the change in the total number of warts (P < .001).
Intralesional injection of combined digoxin and furosemide is safe and effective treatment option in multiple plantar warts.
疣是由人乳头瘤病毒引起的小型良性生长物。目前还没有一种治疗方法被证明能 100%有效治愈。DNA 病毒依赖于 K+内流来进行复制。地高辛和呋塞米通过与细胞膜离子共转运蛋白相互作用来抑制 K+内流。因此，人们假设这两种化合物可能对疣的治疗有价值。
我们旨在评估地高辛和呋塞米联合皮内注射治疗足底疣的疗效和安全性。
患者/方法：这项双臂单盲随机临床试验纳入了 40 例多发性足底疣（≥3 个疣）患者，分为 2 组（每组 20 例）。第一组接受皮内生理盐水注射，第二组接受皮内联合地高辛和呋塞米注射，每周 1 次，最多 5 次注射。
比较两组治疗反应（疣数量减少），第一组疣数量无变化（治疗前 82 个，治疗后 82 个），而第二组治疗前疣数量为 80 个，治疗后为 40 个（数量减少 50%）。两组之间总疣数的变化有统计学显著差异（P<.001）。
地高辛和呋塞米联合皮内注射是治疗多发性足底疣的安全有效方法。
