Duméry V, Blozovski D
Exp Brain Res. 1987;67(1):61-9. doi: 10.1007/BF00269453.
Passive avoidance learning was studied in young rats 13-30 days of age following bilateral injections of saline or antimuscarinic and/or muscarinic agents into three amygdaloid nuclei--lateral (L), basolateral (BL), and cortical (CO). While acquisition was not influenced by saline injections into various other cerebral structures, it was significantly altered by similar injections into these amygdaloid nuclei, especially by those into the BL nucleus, suggesting that this nucleus is particularly involved in passive avoidance learning. Atropine induced significant deficits from as early as 13 days on. These deficits increased and were of similar strength after injections into any of the three studied nuclei until day 16; after that age, they diminished slightly following CO and L nuclei administration, while remaining substantial after BL nucleus injections at all ages, even at 30 days. No facilitatory effects could be elicited by arecoline injected alone, while arecoline could antagonize the disturbing effect of atropine, when given in combination, from day 13 on. These results suggest a muscarinic cholinergic mediation of passive avoidance learning through the synaptic elements located in the basal lateral part of the amygdala in the young rat.
在13至30日龄的幼鼠中研究了被动回避学习。向三个杏仁核——外侧核（L）、基底外侧核（BL）和皮质核（CO）双侧注射生理盐水或抗毒蕈碱和/或毒蕈碱剂。虽然向其他各种脑结构注射生理盐水对习得没有影响，但向这些杏仁核注射类似药物会显著改变习得，尤其是向BL核注射，这表明该核特别参与被动回避学习。阿托品从13天起就导致显著缺陷。这些缺陷不断增加，在向三个研究核中的任何一个注射后，到16天时缺陷强度相似；在那个年龄之后，向CO核和L核给药后缺陷略有减少，而在所有年龄，即使在30天时，向BL核注射后缺陷仍然很大。单独注射槟榔碱不会产生促进作用，而从13天起，槟榔碱与阿托品联合使用时可拮抗阿托品的干扰作用。这些结果表明，幼鼠通过位于杏仁核基底外侧部分的突触元件，以毒蕈碱胆碱能方式介导被动回避学习。
