Ottersen O P
J Comp Neurol. 1982 Feb 10;205(1):30-48. doi: 10.1002/cne.902050104.
The corticoamygdaloid and intraamygdaloid projections of the rat were studied by the use of retrograde transport of horseradish peroxidase (HRP). Observations based on anterograde transport of the enzyme were exploited to determine the course of the intrinsic connections. The HRP was injected stereotactically by means of iontophoresis. Most of the amygdaloid nuclei were selectively injected, and all but a few were reached by more than one approach. The vast majority of corticoamygdaloid fibers was found to originate in cortical areas defined as allocortical (Stephan, '75). From the medial frontal cortex the central amygdaloid nucleus (AC) receives a hitherto undescribed projection originating in the tenia tecta; and both the AC and the lateral amygdaloid nucleus (AL) receive fibers from the prelimbic and infralimbic areas. The anterior cingulate area entertains a weak connection with the basolateral amygdaloid nucleus (BL). As to the insular cortex, the posterior agranular insular area projects to all amygdaloid subdivisions; the BL, AC, and the anterior cortical nucleus (COa) receive, in addition, fibers from the ventral agranular area. The prepyriform cortex connects with the entire amygdala except the medial nucleus (Am). The amygdala receives afferents from a transitional area between the amygdala and the entorhinal area. The entorhinal area proper is related to the amygdala via projections from the ventral part of the lateral entorhinal area to the AL and from the dorsal part of the lateral entorhinal area to the BL. The former nucleus also receives fibers from the perirhinal region. Additional amygdalopetal connections from the hippocampal region include a previously undescribed projection from the temporal two-thirds of CA1 to the AL and BL and to the posterior cortical nucleus (COp) with the adjacent periamygdaloid cortex (PAC). The subiculum projections to the AL, and more modestly to other amygdaloid nuclei. There is an extensive network of intraamygdaloid connections, the Am and AC being the only nuclei not giving rise to the intrinsic fibers.
利用辣根过氧化物酶（HRP）逆行运输法对大鼠的皮质杏仁核和杏仁核内投射进行了研究。基于该酶顺行运输的观察结果被用于确定内在连接的路径。HRP通过离子电渗法进行立体定向注射。大部分杏仁核被选择性注射，除少数外，几乎所有杏仁核都通过不止一种方法到达。发现绝大多数皮质杏仁核纤维起源于被定义为异皮质的皮质区域（斯蒂芬，1975年）。中央杏仁核（AC）从内侧额叶皮质接收来自带状顶盖的迄今未描述的投射；AC和外侧杏仁核（AL）都从边缘前区和边缘下区接收纤维。前扣带区与基底外侧杏仁核（BL）有微弱连接。关于岛叶皮质，后部无颗粒岛叶区投射到所有杏仁核亚区；此外，BL、AC和前皮质核（COa）还从腹侧无颗粒区接收纤维。梨状前皮质与除内侧核（Am）以外的整个杏仁核相连。杏仁核从杏仁核与内嗅区之间的过渡区接收传入纤维。内嗅区本身通过外侧内嗅区腹侧部分向AL的投射以及外侧内嗅区背侧部分向BL的投射与杏仁核相关。前一个核还从梨周区域接收纤维。来自海马区域的额外杏仁核传入连接包括从CA1的颞叶三分之二到AL、BL以及到后皮质核（COp）和相邻杏仁周皮质（PAC）的先前未描述的投射。海马下托投射到AL，对其他杏仁核的投射则较弱。杏仁核内存在广泛的连接网络，Am和AC是仅有的不产生内在纤维的核。
