Harrell L E, Peagler A D, Parsons D S
Exp Neurol. 1987 Sep;97(3):542-54. doi: 10.1016/0014-4886(87)90112-9.
Prior studies from our laboratory suggest that peripheral sympathetic ingrowth, which occurs in the hippocampus following medial septal lesions, is detrimental to the reaquisition of a spatial learning/memory task. To assess the generality of this finding we studied step-through passive-avoidance learning in animals with a medial septal lesion with or without superior cervical ganglionectomy under two experimental conditions. In the first condition, in which no prior experience with the task occurred, animals with a lesion demonstrated facilitation of learning. In the second condition, in which animals received pretraining with no shock prior to surgical manipulation, the behavior of animals with the lesion was similar to that of controls. No effect of ganglionectomy or initial sympathetic ingrowth was found in either condition. The results suggest that the effects of medial septal lesions on passive avoidance behavior are determined by the experimental condition and that early peripheral sympathetic ingrowth does not contribute either in a detrimental or beneficial fashion to passive avoidance learning.
我们实验室之前的研究表明，内侧隔区损伤后海马体中出现的外周交感神经长入，对空间学习/记忆任务的重新习得是有害的。为了评估这一发现的普遍性，我们在两种实验条件下研究了有或没有切除颈上神经节的内侧隔区损伤动物的一步通过式被动回避学习。在第一种条件下，动物没有该任务的先前经验，损伤动物表现出学习促进。在第二种条件下，动物在手术操作前接受了无电击的预训练，损伤动物的行为与对照组相似。在这两种条件下均未发现神经节切除术或初始交感神经长入的影响。结果表明，内侧隔区损伤对被动回避行为的影响取决于实验条件，并且早期外周交感神经长入对被动回避学习既没有有害影响也没有有益作用。
