Bernard E, Strauss B, Haring J, Davis J N
J Neurochem. 1983 Oct;41(4):1171-6. doi: 10.1111/j.1471-4159.1983.tb09068.x.
The cyclic 3'-5' adenosine monophosphate (cyclic AMP) content of the rat hippocampal formation doubles during the week following a medial septal lesion and remains elevated for at least 1 month, the longest time period studied. This elevation in cyclic AMP does not result from sympathetic ingrowth, as neither superior cervical ganglion stimulation nor ganglionectomy influences hippocampal cyclic AMP content after lesions. Interruption of the cholinergic septohippocampal pathway in the fornix did not elevate hippocampal cyclic AMP content. Further, treatment of septal-lesioned animals with oxotremorine or of normal animals with atropine did not influence hippocampal cyclic AMP content. Finally, neither locus ceruleus lesions nor treatment with propranolol affected hippocampal cyclic AMP content. We believe this to be the first report of a sustained elevation in hippocampal cyclic AMP content. Like other long-term events, it is likely to have profound effects on hippocampal function and represents a remarkable brain adaptation to remote injury.
大鼠海马结构中的环磷酸腺苷（cAMP）含量在中隔损伤后的一周内翻倍，并在至少1个月的时间内持续升高，这是研究的最长时间段。cAMP的这种升高并非由交感神经长入引起，因为无论是刺激颈上神经节还是进行神经节切除术，均不会影响损伤后海马的cAMP含量。穹窿中胆碱能中隔-海马通路的中断并未提高海马的cAMP含量。此外，用氧化震颤素处理中隔损伤动物或用阿托品处理正常动物，均不影响海马的cAMP含量。最后，蓝斑损伤或用普萘洛尔治疗均未影响海马的cAMP含量。我们认为这是关于海马cAMP含量持续升高的首次报道。与其他长期事件一样，它可能对海马功能产生深远影响，代表了大脑对远期损伤的显著适应性变化。
