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立体选择性标记的胆色素原的合成及其掺入原卟啉-IX中。

The synthesis of stereoselectively labelled porphobilinogen and its incorporation into protoporphyrin-IX.

作者信息

Jackson A H, Lertwanawatana W, Procter G, Smith S G

出版信息

Experientia. 1987 Aug 15;43(8):892-4. doi: 10.1007/BF01951654.

DOI:10.1007/BF01951654
PMID:3622732
Abstract

11-(R)-2H porphobilinogen, stereospecifically labelled with deuterium in the aminomethylene group has been incorporated into protoporphyrin-IX by haemolysates of chicken erythrocytes. High field NMR spectroscopy confirms that the overall biochemical process is stereospecific, deuterium being retained at the alpha-, gamma- and delta-meso positions and lost from the beta-meso position.

摘要

11-(R)-2H 卟啉原,其氨基亚甲基上用氘进行了立体特异性标记,已被鸡红细胞溶血产物掺入原卟啉-IX 中。高场核磁共振光谱证实整个生化过程是立体特异性的,氘保留在α-、γ-和δ-中位位置,并从β-中位位置丢失。

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引用本文的文献

1
Porphobilinogen deaminase and uroporphyrinogen III synthase: structure, molecular biology, and mechanism.胆色素原脱氨酶和尿卟啉原III合酶:结构、分子生物学及作用机制
J Bioenerg Biomembr. 1995 Apr;27(2):181-95. doi: 10.1007/BF02110033.

本文引用的文献

1
Conversion of coproporphyrinogen 3 to protoporphyrin IX.粪卟啉原Ⅲ向原卟啉Ⅸ的转化。
Enzyme. 1974;17(1):81-7. doi: 10.1159/000459311.
2
Biosynthesis of porphyrins and related macrocycles. Part V. Structural integrity of the type III porphyrinogen macrocycle in an active biological system; studies on the aromatisation of protoporphyrinogen-IX.卟啉及相关大环化合物的生物合成。第五部分。活性生物体系中III型卟啉原大环的结构完整性;原卟啉原-IX芳构化的研究。
J Chem Soc Perkin 1. 1976(3):266-73. doi: 10.1039/p19760000266.