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职业性接触石棉中的红细胞原卟啉IX

[Erythrocyte protoporphyrin IX in occupational exposure to asbestos].

作者信息

Stankiewicz A

出版信息

Med Pr. 1984;35(5):351-4.

PMID:6530952
Abstract

Analysis of the dependence of protoporphyrin IX in erythrocytes upon non-exposed populations age. The study was performed in 246 persons (104 women and 142 men) who were not occupationally exposed to toxic agents. The women were aged 19-72, the men 19-76. The mean concentrations of protoporphyrin IX for those groups do not differ significantly. To test the dependence of protoporphyrin IX concentration upon age, the women and men were divided into three age subgroups: under 30, 31-40, and over 40. The statistical analysis indicated different distribution of mean protoporphyrin IX concentrations at those age intervals in both test groups, no significant difference between those values being found. Effects of asbestos upon protoporphyrin IX concentrations in erythrocytes in occupational exposure. Sixty three persons were examined (27 women and 36 men), workers of the Plant of Asbestos Seals and Products, "POLONIT", Lódź. The exposure lasted 1-35 years. Age intervals: women 25-64, men 25-63. The estimated mean protoporphyrin IX concentrations both for women (51.2 mg%) and men (47.6 mg%) differ significantly from the mean values of relevant control groups (39.3 and 37.6). In addition, ferrum concentration in serum and hemoglobin concentration in blood in the mentioned groups were analysed. All the findings were within the physiological values.

摘要

分析红细胞中原卟啉IX含量与未接触人群年龄的相关性。研究对象为246名未接触职业性毒物的人群(104名女性和142名男性)。女性年龄在19至72岁之间,男性年龄在19至76岁之间。这些组中原卟啉IX的平均浓度无显著差异。为检验原卟啉IX浓度与年龄的相关性,将女性和男性分为三个年龄亚组:30岁以下、31至40岁、40岁以上。统计分析表明,两个测试组在这些年龄区间的原卟啉IX平均浓度分布不同,但这些值之间未发现显著差异。职业接触石棉对红细胞中原卟啉IX浓度的影响。对63名人员进行了检查(27名女性和36名男性),他们是罗兹市“POLONIT”石棉密封材料和产品厂的工人。接触时间为1至35年。年龄区间:女性25至64岁,男性25至63岁。女性(51.2mg%)和男性(47.6mg%)的原卟啉IX估计平均浓度与相应对照组的平均值(39.3和37.6)有显著差异。此外,还分析了上述组血清中的铁浓度和血液中的血红蛋白浓度。所有结果均在生理值范围内。

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