一种新型小动物心肌模型的研制可用于评估双同位素同时采集（DISA）的图像质量。
Development of a novel small-animal myocardial phantom can evaluate the image quality of dual-isotope simultaneous acquisition (DISA).
机构信息
Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 5-11-80, Kodatsuno, Kanazawa, Japan.
Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
出版信息
Ann Nucl Med. 2022 Dec;36(12):1031-1038. doi: 10.1007/s12149-022-01791-z. Epub 2022 Oct 13.
BACKGROUND
Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal fields. However, the previous phantom did not reproduce the structures of rats or mice. The aim of this study was to develop a novel myocardial phantom simulating the structure of a small animal that can be evaluated using the image quality of DISA.
METHODS
A novel small-animal myocardial phantom that simulated a rat was constructed by the myocardium, liver, lung, spine, and torso. Normal and inferior wall defect myocardial phantoms were filled with Tc or F solution to simulate single-isotope acquisition (SIA) and DISA. Phantom and small-animal images with no scatter correction (nonSC) and scatter correction (SC) were created.
RESULTS
The Tc DISA with SC showed a low %CV compared to that with nonSC. Although the Tc DISA with nonSC had lower cavity contrast than that of Tc SIA with nonSC, the cavity contrast of SC had similar values between SIA and DISA. The minimum %uptake of Tc SIA with nonSC was a lower value compared to that of Tc DISA with nonSC. The Tc DISA was equivalent to the minimum %uptake of Tc SIA by SC.
CONCLUSION
We have developed a novel myocardial phantom for the rat model to evaluate the image quality for reproducing the physical phenomenon associated with radiation attenuation and scattering. Furthermore, we could demonstrate the usefulness of the novel small-animal myocardial phantom by image quality evaluation of DISA with Tc and F compared to SIA.
背景
心肌体模研究被广泛用作准确评估小动物领域双同位素同时采集（DISA）物理现象的工具。然而，以前的体模并未再现大鼠或小鼠的结构。本研究旨在开发一种新的心肌体模，模拟小动物的结构，可以使用 DISA 的图像质量进行评估。
方法
通过心肌、肝脏、肺、脊柱和躯干构建了一种模拟大鼠的新型小动物心肌体模。正常和下壁缺陷心肌体模填充 Tc 或 F 溶液以模拟单同位素采集（SIA）和 DISA。创建了无散射校正（nonSC）和散射校正（SC）的体模和小动物图像。
结果
与 nonSC 相比，Tc DISA 与 SC 具有较低的 %CV。尽管 Tc DISA 与 nonSC 的腔对比度低于 Tc SIA 与 nonSC，但 SC 的腔对比度在 SIA 和 DISA 之间具有相似的值。Tc SIA 与 nonSC 的最小 %摄取值低于 Tc DISA 与 nonSC。Tc DISA 与 SC 的最小 %摄取值与 Tc SIA 相当。
结论
我们已经开发了一种用于大鼠模型的新型心肌体模，以评估再现与辐射衰减和散射相关的物理现象的图像质量。此外，我们通过比较 Tc 和 F 的 DISA 与 SIA 的图像质量评估，展示了新型小动物心肌体模的有用性。
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