血小板活化因子对血管紧张素I向血管紧张素II转化的影响。

Effects of platelet-activating factor on conversion of angiotensin I to II.

作者信息

Kawaguchi H, Yasuda H

出版信息

FEBS Lett. 1987 Sep 14;221(2):305-8. doi: 10.1016/0014-5793(87)80945-6.

Abstract

We have studied the effects of platelet-activating factor (alkyl-acetyl-GPC) on conversion of angiotensin I to II. Platelet-activating factor (PAF) had a novel effect on angiotensin I conversion. Pulmonary artery endothelial cells converted 30% of [125I]angiotensin I to angiotensin II in the absence of PAF, but their activity was greatly stimulated in its presence. When PAF was added to pulmonary artery endothelial cells, the conversion of angiotensin I to II was enhanced up to 68%. Maximal stimulation without cellular damage was achieved at 10(-5) M PAF. LysoPAF did not stimulate the conversion of angiotensin I to angiotensin II at any concentration used.

摘要

我们研究了血小板活化因子（烷基 - 乙酰 - GPC）对血管紧张素I向II转化的影响。血小板活化因子（PAF）对血管紧张素I转化有新的作用。在没有PAF的情况下，肺动脉内皮细胞将30%的[125I]血管紧张素I转化为血管紧张素II，但在其存在时其活性受到极大刺激。当将PAF添加到肺动脉内皮细胞时，血管紧张素I向II的转化增强至68%。在10^(-5) M PAF时可在不造成细胞损伤的情况下实现最大刺激。溶血PAF在所用的任何浓度下均未刺激血管紧张素I向血管紧张素II的转化。