Ophthalmology Department, Rothschild Foundation Hospital, Paris, France.
Ocul Immunol Inflamm. 2023 Aug;31(6):1240-1244. doi: 10.1080/09273948.2022.2127782. Epub 2022 Oct 13.
To report two cases of multiple evanescent white dot syndrome (MEWDS) following COVID-19 vaccination with the BNT162b2 mRNA vaccine.
Two case reports. Case-1: A 40-yo Caucasian male, complained of blurred and decrease of vision in his left eye (OS) one week after the first dose of the BNT162b2 mRNA SARS-CoV-2 vaccine. Funduscopic examination OS showed multiple granular white dots with an aspect of foveal granularity. Case-2: A 23-yo woman also presented with defective and decrease of vision OS. She received her first dose of the BNT162b2 mRNA SARS-CoV-2 vaccine ten days before. Dilated fundus examination OS showed altered macular reflex with an aspect of foveal granularity.
Multimodal imaging showed features of MEWDS in both cases. The anomalies found resolved spontaneously after 6 weeks.
Inflammation and immune dysregulation induced by COVID-19 mRNA vaccine or its adjuvants could be involved in ocular adverse effects.
报告两例接种 BNT162b2 mRNA 疫苗后发生多发性一过性白点综合征（MEWDS）的病例。
两例病例报告。病例 1：一名 40 岁的白人男性，在接种 BNT162b2 mRNA SARS-CoV-2 疫苗第一剂后一周出现左眼（OS）视力模糊和下降。OS 的眼底检查显示多个颗粒状白色斑点，呈黄斑颗粒状。病例 2：一名 23 岁女性，也出现 OS 视力缺陷和下降。她在十天前接种了第一剂 BNT162b2 mRNA SARS-CoV-2 疫苗。OS 的散瞳眼底检查显示黄斑反射改变，呈黄斑颗粒状。
多模态成像显示两例均存在 MEWDS 的特征。6 周后，异常自行消退。
COVID-19 mRNA 疫苗或其佐剂引起的炎症和免疫失调可能与眼部不良反应有关。
