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[肾脏中单一加氧酶系统的诱导及外源性物质的转运]

[Induction of the monooxygenase system and the transport of xenobiotics in the kidney].

作者信息

Berkhin E B, Lampatov V V, Ul'ianov G P

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1987 May;73(5):685-8.

PMID:3622832
Abstract

Phenobarbital (50 mg/kg) and benzonal (35 mg/kg) orally for 4 days and 3-methylcholanthrene (20 mg/kg) subcutaneously increased the excretion and tubular maximal transport of cardiotrast (diodrast) in rats. The inductors of the monooxigenase system seem to stimulate the renal transport of xenobiotics.

摘要

苯巴比妥(50毫克/千克)和苯佐那尔(35毫克/千克)口服4天,以及3-甲基胆蒽(20毫克/千克)皮下注射,均可增加大鼠心造影剂(碘司特)的排泄及肾小管最大转运量。单加氧酶系统诱导剂似乎能刺激外源化学物的肾脏转运。

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