Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, China.
Department of Radiology, Affiliated Hospital of Zunyi Medical University, Medical Imaging Center of Guizhou Province, Zunyi, China; Department of Radiology, Suining Central Hospital, Suining, China.
Epilepsy Behav. 2022 Nov;136:108940. doi: 10.1016/j.yebeh.2022.108940. Epub 2022 Oct 10.
Self-limited epilepsy with centrotemporal spikes (SLECTS) is a pediatric benign epilepsy but often accompanied by subsequent (in adulthood) functional changes such as language, which are thought to have distinct areas of hemispheric lateralization and functional differentiation. This study aimed to explore hemispheric specialization measured by resting-state functional magnetic resonance imaging (rs-fMRI) functional connectivity in drug-naïve and drug-receiving SLECTS.
Hemispheric specialization was quantified in three groups of children, including 21 drug-naïve patients (DNP) with SLECTS, 34 drug-receiving patients (DRP) with SLECTS and 36 demographically matched typical development (TD).
Compared with the TD group, both the DNP and DRP groups exhibited significantly higher specialization in the left superior temporal gyrus, right parahippocampus, left putamen, and right caudate. The DNP group exhibited significantly higher hemispheric specialization in the right precentral gyrus and right inferior temporal gyrus, while the DRP group demonstrated significantly higher hemispheric specialization in the left postcentral gyrus and right hippocampus than the TD group. Furthermore, bilateral cerebellum_6 showed opposing hemispheric specialization trends in the two patient groups. Further meta-analytical mapping demonstrated that hemispheric specialization-related differential brain regions are primarily involved in language processing.
Our findings showed that children with SLECTS had altered hemispheric specialization, mainly in language processing regions, suggesting both abnormal intrahemispheric segregation and interhemispheric integration in these children.
中央颞区棘波的良性儿童癫痫（SLECTS）是一种儿科良性癫痫，但常伴有随后（成年后）的功能改变，如语言，这些改变被认为具有明显的半球侧化和功能分化区域。本研究旨在探讨未用药和用药的 SLECTS 患者静息态功能磁共振成像（rs-fMRI）功能连接测量的半球特化。
在三组儿童中量化了半球特化，包括 21 名未经药物治疗的 SLECTS 患者（DNP）、34 名接受药物治疗的 SLECTS 患者（DRP）和 36 名年龄匹配的典型发育（TD）儿童。
与 TD 组相比，DNP 和 DRP 组在左侧颞上回、右侧海马旁回、左侧壳核和右侧尾状核的特化程度均显著升高。DNP 组在右侧中央前回和右侧颞下回的半球特化程度显著升高，而 DRP 组在左侧中央后回和右侧海马的半球特化程度显著高于 TD 组。此外，双侧小脑_6 在两个患者组中表现出相反的半球特化趋势。进一步的元分析映射表明，半球特化相关的差异脑区主要参与语言处理。
我们的发现表明，SLECTS 患儿存在半球特化改变，主要在语言处理区域，提示这些患儿存在异常的半球内分离和半球间整合。
