多模式治疗对乳腺癌癌因性疲劳患者静息/活动和自主神经调节的影响：一项具有综合队列设计的三中心试验的结果。
Influence of Multimodal Treatment on Rest/Activity and Autonomic Regulation in Breast Cancer Patients with Cancer-Related Fatigue: Results of a Tri-Centre Trial with a Comprehensive Cohort Design.
机构信息
Research Institute Havelhöhe (FIH), Berlin, Germany.
Department of Internal Medicine, Gemeinschaftskrankenhaus Havelhöhe, Berlin, Germany.
出版信息
Complement Med Res. 2023;30(2):115-129. doi: 10.1159/000527354. Epub 2022 Oct 13.
INTRODUCTION
Breast cancer patients with cancer-related fatigue (BC-CRF) often have lower physical activity. To investigate how this could be improved, we evaluated a multimodal treatment (MT) and a combination of MT with aerobic training (CT) and compared these with aerobic training (AT) regarding rest/activity rhythm and state autonomic regulation (State aR).
METHODS
In this pragmatic comprehensive cohort design study, the explorative analysis focused on actigraphy and State aR including the rest/activity regulation subscale (State aR-R/A) which were assessed at baseline (T0), after 10 weeks of intervention (T1), and State aR additionally 6 months later (T2).
STATISTICS
General linear modelling including propensity scores.
RESULTS
65 BC-CRF were randomized, and 61 were allocated by preference to the treatment arms. 105 patients started the intervention. At T1, State aR-R/A improved the most in MT (+3.49, CI [2.42; 4.55]) compared to AT (+1.59, CI [0.13; 3.06]) and CT (+1.68, CI [0.83; 2.52]), showing superiority of MT to AT (p = 0.048). At T2 MT was sustainably superior to AT regarding State aR-R/A (+3.61, CI [2.38; 4.83] p < 0.01) and State aR also showed superiority of MT to AT (p = 0.006). AT T1 24-h activity was higher in MT compared to AT (p = 0.029).
CONCLUSIONS
MT was superior to AT regarding State aR total score after 6 months, State aR-R/A after 10 weeks, and after 6 months. Actigraphically measured total activity also improved after 10 weeks.
简介
患有癌因性疲乏（BC-CRF）的乳腺癌患者通常体力活动较少。为了研究如何改善这种情况，我们评估了一种多模式治疗（MT）和有氧运动训练（CT）与 MT 联合治疗，并将这些治疗与有氧运动训练（AT）进行了比较，比较了它们对休息/活动节律和自主状态调节（State aR）的影响。
方法
在这项实用综合队列设计研究中，探索性分析侧重于活动记录仪和 State aR，包括状态自主调节子量表（State aR-R/A），在基线（T0）、干预 10 周后（T1）和 State aR 后 6 个月（T2）进行评估。
统计
包括倾向评分的一般线性模型。
结果
65 名 BC-CRF 患者被随机分组，61 名患者根据偏好分配到治疗组。105 名患者开始接受干预。在 T1 时，与 AT（+1.59，CI [0.13；3.06]）和 CT（+1.68，CI [0.83；2.52]）相比，MT 对 State aR-R/A 的改善最大（+3.49，CI [2.42；4.55]），表明 MT 比 AT 更优越（p = 0.048）。在 T2 时，MT 在 State aR-R/A 方面持续优于 AT（+3.61，CI [2.38；4.83]，p < 0.01），并且 State aR 也显示 MT 比 AT 优越（p = 0.006）。在 T1 时，与 AT 相比，MT 的 24 小时活动量更高（p = 0.029）。
结论
在 6 个月后，MT 在 State aR 总分、10 周后 State aR-R/A 和 6 个月后 State aR-R/A 方面均优于 AT。10 周后，活动记录仪测量的总活动量也有所改善。
Zotero 插件