Calanchini-Postizzi E, Frenk E
Dermatologica. 1987;174(6):266-71. doi: 10.1159/000249197.
Vitiligo provides a model system for studying chronic actinic damage in skin devoid of melanin pigments and thereby permits assessment of their photoprotective function. Our study comprised 23 patients with a mean age of 67 years having stable, long-lasting vitiligo on light-exposed body regions. The vitiliginous and normally pigmented, light-exposed skin was examined clinically for manifestations of chronic actinic damage. In 11 patients skin biopsies were obtained from vitiliginous and adjacent pigmented skin for qualitative and quantitative histological comparison. Our study did not reveal evidence for a significant increase of chronic actinic damage in skin devoid of melanin pigments. These results are in agreement with the rareness of reported skin cancer in vitiligo.
白癜风为研究缺乏黑色素的皮肤中的慢性光化损伤提供了一个模型系统，从而能够评估黑色素的光保护功能。我们的研究纳入了23例平均年龄为67岁的患者，这些患者在光暴露身体部位患有稳定、持久的白癜风。对白癜风皮肤及正常色素沉着的光暴露皮肤进行临床检查，以观察慢性光化损伤的表现。11例患者从白癜风皮肤及相邻色素沉着皮肤处获取皮肤活检样本，进行定性和定量组织学比较。我们的研究未发现缺乏黑色素的皮肤中慢性光化损伤显著增加的证据。这些结果与白癜风患者中报道的皮肤癌罕见情况一致。
