丙嗪与人铜蓝蛋白的相互作用。
Interaction of promazine with human ceruloplasmin.
作者信息
Løvstad R A
出版信息
Int J Biochem. 1987;19(7):649-52. doi: 10.1016/0020-711x(87)90232-1.
PMID:3622897
Abstract
Promazine is enzymically oxidized by ceruloplasmin without reduction of the 610 nm absorption band of the enzyme. Fluoride inhibited the reaction in a non-competitive manner. The ceruloplasmin oxidase activity is markedly enhanced when promazine is added in the presence of NADH; possibly through a change in enzyme conformation.
摘要
丙嗪可被铜蓝蛋白酶促氧化，且不会使该酶610 nm吸收带发生还原。氟化物以非竞争性方式抑制该反应。当在NADH存在的情况下加入丙嗪时，铜蓝蛋白氧化酶活性会显著增强；可能是通过酶构象的改变实现的。
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