Chen H F, Zhang Z J, You C J, Chen L
Emergency Department of Banan District People's Hospital of Chongqing, Chongqing 401320, China.
Emergency Department of Banan District People's Hospital of Chongqing, Chongqing 401320, China Critical Care Medicine of Banan District People's Hospital of Chongqing, Chongqing 401320, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 Sep 20;40(9):707-709. doi: 10.3760/cma.j.cn121094-20210617-00295.
Bromadiolone, commonly known as super warfarin, is a long-acting coumarin dicoumarin rodenticide. The mechanism of bromadiolone is mainly to inhibit vitamin K1 epoxide reductase and affect the synthesis of coagulation factors Ⅱ, Ⅶ, Ⅸ and Ⅹ, which causes blood coagulation dysfunction and systemic multiple organ hemorrhage. Here, we report of a case of bromadiolone poisoning patient who had digestive tract, abdominal hemorrhage, as well as secondary paralytic ileus. After blood product transfusion and vitamin K1 supplementation, the patient was discharged after the physical condition was improved. It's suggestied that clinicians should pay attention to rare complications to prevent missed diagnosis when treating other bromadiolone poisoning.
溴敌隆，通常被称为超级华法林，是一种长效香豆素类双香豆素灭鼠剂。溴敌隆的作用机制主要是抑制维生素K1环氧化物还原酶，影响凝血因子Ⅱ、Ⅶ、Ⅸ和Ⅹ的合成，从而导致凝血功能障碍和全身多器官出血。在此，我们报告一例溴敌隆中毒患者，该患者出现消化道、腹腔出血以及继发性麻痹性肠梗阻。在输注血液制品和补充维生素K1后，患者身体状况改善后出院。建议临床医生在治疗其他溴敌隆中毒时应注意罕见并发症，以防漏诊。
