Tasman-Jones C, Maher C, Thomsen L, Lee S P, Vanderwee M
Digestion. 1987;37 Suppl 2:1-7.
Peptic ulcer disease occurs when there is an imbalance between aggressive factors and mucosal resistance. Mucus plays a key role in mucosal resistance. The mucus layer is relatively resistant to peptic digestion, it provides a layer through which there is a movement of hydrogen ions from the parietal cell to the lumen but a resistance to back-diffusion of hydrogen ions in the opposite direction. It maintains a pH gradient by 'sequestering' secreted bicarbonate and by its resistance to H+ back-diffusion. Colloidal bismuth subcitrate (De-Nol) binds to mucus to stabilize the mucous layer and increase the resistance to back-diffusion of hydrogen ions without significantly modifying the ion-exchange properties of mucus.
当攻击因子与黏膜抵抗力之间出现失衡时，就会发生消化性溃疡病。黏液在黏膜抵抗力中起关键作用。黏液层对消化性消化相对具有抗性，它提供了一层介质，氢离子可通过该层从壁细胞移动到管腔，但对氢离子反向扩散具有抗性。它通过“隔离”分泌的碳酸氢盐并对氢离子反向扩散产生抗性来维持pH梯度。枸橼酸铋钾（得乐）与黏液结合，以稳定黏液层并增加对氢离子反向扩散的抵抗力，而不会显著改变黏液的离子交换特性。
