Department of Periodontology, School of Dentistry, Faculty of Health, Witten/Herdecke University, Alfred-Herrhausen Str. 45, 58455, Witten, Germany.
Faculty of Health, Center for Biomedical Education and Research (ZBAF), Institute of Pharmacology and Toxicology, Witten/Herdecke University, Stockumer Straße 10, 58453, Witten, Germany.
Clin Oral Investig. 2023 Mar;27(3):1167-1175. doi: 10.1007/s00784-022-04731-3. Epub 2022 Oct 13.
The aim of this study was to assess the microcirculation and the expression patterns of wound-healing-related cytokines around narrow-diameter implants in type 2 diabetes mellitus (T2DM) and normo-glycemic patients.
A total of 31 patients, 16 of which diagnosed with T2DM (HbA1c > 6.5) and 15 normo-glycemic patients, received narrow diameter implants in the posterior mandible or maxilla. During the 3-month healing period, soft-tissue perfusion was monitored via laser Doppler flowmetry. Peri-implant fluid (PICF) was harvested and analyzed for concentrations of interleukin-1ß (IL-1ß), interleukin-23 (IL-23), interleukin-17 (IL-17), and granulocyte colony-stimulating factor (G-CSF) by a multiplex, bead-based immunoassay.
Microcirculatory perfusion patterns during wound healing exhibited no significant differences throughout the observation period. IL-1ß concentrations were expectedly elevated during the early phases of wound healing. At the first visit after surgery, IL-23 concentrations were significantly higher in implants of diabetic patients. This difference was diminished over the course of the observation period. For the other tested analytes, no differences were observable between both groups.
Wound healing after implant surgery was similar in T2DM and healthy patients. Hydrophilic-surface titanium-zirconium implants with reduced diameter may be considered for implant therapy of diabetes mellitus type II patients.
NCT04630691 (clinicaltrials.gov).
本研究旨在评估 2 型糖尿病（T2DM）和血糖正常患者中，窄径种植体周围的微循环和与伤口愈合相关细胞因子的表达模式。
共纳入 31 名患者，其中 16 名被诊断为 T2DM（HbA1c＞6.5），15 名血糖正常的患者。这些患者在下颌后区或上颌植入了窄径种植体。在 3 个月的愈合期内，通过激光多普勒流量仪监测软组织灌注情况。收集种植体周围液（PICF），并通过基于微珠的多重免疫分析检测白细胞介素 1β（IL-1β）、白细胞介素 23（IL-23）、白细胞介素 17（IL-17）和粒细胞集落刺激因子（G-CSF）的浓度。
在整个观察期间，愈合过程中的微循环灌注模式没有明显差异。IL-1β浓度在伤口愈合的早期阶段升高。手术后第一次就诊时，糖尿病患者种植体中的 IL-23 浓度明显更高。这种差异在观察期间逐渐减小。对于其他测试的分析物，两组之间没有观察到差异。
T2DM 和健康患者的种植体手术后愈合情况相似。亲水表面钛锆合金种植体，直径减小，可考虑用于 II 型糖尿病患者的种植体治疗。
NCT04630691（clinicaltrials.gov）。
