Li Xue, Liu Hao, Yang Hui-Rong, Zeng Ying-Jie
College of Food Science & Technology, Southwest Minzu University, Chengdu 610041, China.
Foods. 2022 Oct 5;11(19):3101. doi: 10.3390/foods11193101.
In the study, the structural features and hypoglycemic effects of a polysaccharide Pan from the root of were investigated. The molecular weight of Pan was 8.27 kDa. Structural analysis indicated that Pan mainly consisted of →3)-β-L-Rha-(1→, →3,6)-β-D-Gal-(1→ and →6)-β-D-Gal-(1→ residues with acetyl groups. Pan exhibited good antioxidant activity. Pan could slow down the body weight and the content of blood glucose in the high-fat diet-induced mice, further suppress GLUT-2 and SGLT-1 expression in the intestines, and enhance p-IRS and p-AMPK expression in the livers, finally exhibiting hypoglycemic effects. The results could supply a direction for further research on polysaccharides as components for the control of hyperglycemia induced by obesity and diabetes.
在该研究中，对从[植物名称]根部提取的一种多糖Pan的结构特征和降血糖作用进行了研究。Pan的分子量为8.27 kDa。结构分析表明，Pan主要由→3)-β-L-鼠李糖-(1→、→3,6)-β-D-半乳糖-(1→和→6)-β-D-半乳糖-(1→残基以及乙酰基组成。Pan表现出良好的抗氧化活性。Pan可以减缓高脂饮食诱导的小鼠体重和血糖含量的增加，进一步抑制肠道中GLUT-2和SGLT-1的表达，并增强肝脏中p-IRS和p-AMPK的表达，最终呈现出降血糖作用。这些结果可为进一步研究多糖作为控制肥胖和糖尿病引起的高血糖的成分提供方向。
