Menna Cecilia, Rendina Erino Angelo, D'Andrilli Antonio
Division of Thoracic Surgery, Sant'Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.
Cancers (Basel). 2022 Sep 30;14(19):4782. doi: 10.3390/cancers14194782.
Reconstruction of the pulmonary artery (PA) associated with lobectomy for the radical resection of lung cancer has been progressively gaining diffusion in lung cancer surgery as a safe and effective therapeutic option that may allow radical resection when lobectomy is not technically feasible, avoiding pneumonectomy. There are some controversial aspects concerning the intraoperative and perioperative management of a sleeve resection with PA reconstruction that may influence the outcome. In the present article, the authors have analyzed some of the main technical and oncological aspects to take stock of what they have learned from their lung-sparing operations experience over time. PA reconstruction may require prosthetic materials including different options with variable cost. A main concern in vascular reconstructive procedures is avoiding tension on the anastomosis. When PA reconstruction is required, appropriate anticoagulation management is crucial. Results from the main literature data confirm the reliability of lobectomy associated with PA reconstruction in terms of perioperative morbidity and long-term survival. Sleeve lobectomy and PA reconstruction can be performed safely and effectively even after induction therapy.
与肺癌根治性切除的肺叶切除术相关的肺动脉(PA)重建,作为一种安全有效的治疗选择,在肺癌手术中已逐渐得到广泛应用。当肺叶切除术在技术上不可行时,该方法可实现根治性切除,避免全肺切除术。关于伴有PA重建的袖状切除术的术中及围手术期管理,存在一些有争议的方面,这些方面可能会影响手术结果。在本文中,作者分析了一些主要的技术和肿瘤学方面,以总结他们长期以来从肺保留手术经验中学到的知识。PA重建可能需要假体材料,包括不同的选择,成本各异。血管重建手术中的一个主要问题是避免吻合口处的张力。当需要进行PA重建时,适当的抗凝管理至关重要。主要文献数据的结果证实了在围手术期发病率和长期生存率方面,与PA重建相关的肺叶切除术的可靠性。即使在诱导治疗后,也可以安全有效地进行袖状肺叶切除术和PA重建。