消化性溃疡病与胃癌之间的关联：胃癌合并（StoP）项目联盟的结果

The Association between Peptic Ulcer Disease and Gastric Cancer: Results from the Stomach Cancer Pooling (StoP) Project Consortium.

作者信息

Paragomi Pedram, Dabo Bashir, Pelucchi Claudio, Bonzi Rossella, Bako Abdulaziz T, Sanusi Nabila Muhammad, Nguyen Quan H, Zhang Zuo-Feng, Palli Domenico, Ferraroni Monica, Vu Khanh Truong, Yu Guo-Pei, Turati Federica, Zaridze David, Maximovitch Dmitry, Hu Jinfu, Mu Lina, Boccia Stefania, Pastorino Roberta, Tsugane Shoichiro, Hidaka Akihisa, Kurtz Robert C, Lagiou Areti, Lagiou Pagona, Camargo M Constanza, Curado Maria Paula, Lunet Nuno, Vioque Jesus, Boffetta Paolo, Negri Eva, La Vecchia Carlo, Luu Hung N

机构信息

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15232, USA.

Epidemiology and Biostatistics Concentration, College of Public Health, University of South Florida, Tampa, FL 33620, USA.

出版信息

Cancers (Basel). 2022 Oct 7;14(19):4905. doi: 10.3390/cancers14194905.

DOI:10.3390/cancers14194905

PMID:36230828

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9563899/

Abstract

BACKGROUND

Gastric cancer (GC) is the fifth most common type of cancer and the fourth most common cause of cancer-related mortality. Although the risk of GC and peptic ulcer disease (PUD) is known to be increased by infection, evidence regarding the direct relationship between PUD and GC across ethnicities is inconclusive. Therefore, we investigated the association between PUD and GC in the Stomach cancer Pooling (StoP) consortium.

METHODS

History of peptic ulcer disease was collected using a structured questionnaire in 11 studies in the StoP consortium, including 4106 GC cases and 6922 controls. The two-stage individual-participant data meta-analysis approach was adopted to generate a priori. Unconditional logistic regression and Firth's penalized maximum likelihood estimator were used to calculate study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between gastric ulcer (GU)/duodenal ulcer (DU) and risk of GC.

RESULTS

History of GU and DU was thoroughly reported and used in association analysis, respectively, by 487 cases (12.5%) and 276 controls (4.1%), and 253 cases (7.8%) and 318 controls (6.0%). We found that GU was associated with an increased risk of GC (OR = 3.04, 95% CI: 2.07-4.49). No association between DU and GC risk was observed (OR = 1.03, 95% CI: 0.77-1.39).

CONCLUSIONS

In the pooled analysis of 11 case-control studies in a large consortium (i.e., the Stomach cancer Pooling (StoP) consortium), we found a positive association between GU and risk of GC and no association between DU and GC risk.

摘要

背景

胃癌（GC）是第五大常见癌症类型，也是癌症相关死亡的第四大常见原因。尽管已知幽门螺杆菌感染会增加患胃癌和消化性溃疡疾病（PUD）的风险，但关于不同种族中PUD与GC之间直接关系的证据尚无定论。因此，我们在胃癌合并研究（StoP）联盟中调查了PUD与GC之间的关联。

方法

在StoP联盟的11项研究中，通过结构化问卷收集消化性溃疡疾病史，包括4106例GC病例和6922例对照。采用两阶段个体参与者数据荟萃分析方法进行先验分析。使用无条件逻辑回归和Firth惩罚最大似然估计器来计算胃溃疡（GU）/十二指肠溃疡（DU）与GC风险之间关联的研究特异性比值比（OR）和95%置信区间（CI）。

结果

分别有487例病例（12.5%）和276例对照（4.1%）详细报告了GU病史并用于关联分析，以及253例病例（7.8%）和318例对照（6.0%）详细报告了DU病史并用于关联分析。我们发现GU与GC风险增加相关（OR = 3.04，95%CI：2.07 - 4.49）。未观察到DU与GC风险之间存在关联（OR = 1.03，95%CI：0.77 - 1.39）。