Ikeda Yuka, Taniguchi Kurumi, Sawamura Haruka, Yoshikawa Sayuri, Tsuji Ai, Matsuda Satoru
Department of Food Science and Nutrition, Nara Women's University, Kita-Uoya Nishimachi, Nara 630-8506, Japan.
Cancers (Basel). 2022 Oct 8;14(19):4931. doi: 10.3390/cancers14194931.
The APRO family members may be involved in the regulation of cell growth, migration, and/or invasion. Although an APRO protein could suppress the invasiveness of several cancer cells, it has been reported that overexpression of the same APRO protein could also promote the invasiveness and/or metastasis of the same cancer cells. In general, the invasiveness of cancer cells might be associated with the function of matrix metalloproteinases (MMPs) as well as with the function of certain exosomes. However, it has been shown that exosomes involving particular APRO proteins, MMPs, and/or microRNA could contribute to the regulation of invasiveness. Here, we discuss contradictory reports on invasiveness in relation to APRO family proteins on the basis of understanding the function of MMPs and/or various exosomes. A better understanding of those mechanisms could be of use to bring about innovative strategies for cancer treatment.
APRO家族成员可能参与细胞生长、迁移和/或侵袭的调节。尽管一种APRO蛋白可以抑制几种癌细胞的侵袭性，但有报道称，同一APRO蛋白的过表达也可以促进同一癌细胞的侵袭性和/或转移。一般来说，癌细胞的侵袭性可能与基质金属蛋白酶（MMPs）的功能以及某些外泌体的功能有关。然而，已经表明，涉及特定APRO蛋白、MMPs和/或微小RNA的外泌体可能有助于侵袭性的调节。在此，我们在理解MMPs和/或各种外泌体功能的基础上，讨论关于APRO家族蛋白侵袭性的相互矛盾的报道。更好地理解这些机制可能有助于带来创新的癌症治疗策略。
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