Wang Lindsey, Xu Rong, Kaelber David C, Berger Nathan A
Center for Science, Health, and Society, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Center for Artificial Intelligence in Drug Discovery, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
Cancers (Basel). 2022 Oct 9;14(19):4948. doi: 10.3390/cancers14194948.
Purpose: To examine time trends of incidence rates of EOCRC from 2010 to 2021 among patients with and without diverticular disease and to examine whether diverticular disease is associated with increased risk of EOCRC. Methods: This is a retrospective cohort study of 46,179,351 young adults aged 20−49, including 298,117 with diverticular disease. We examined yearly incidence rate of first diagnosis of EOCRC from 2010 through 2021 among patients with and without diverticular disease. The 5-year risk of EOCRC among patients with pre-existing diverticular disease was compared to propensity-matched patients without diverticular disease and EOCRC and odds ratio (OR) and 95% confidence interval (CI) were calculated. Results: The yearly incidence rate of new diagnosis of EOCRC (measured as new cases per 100,000 people per year) in young adults with pre-existing diverticular disease increased from 100 in 2010 to 402 in 2021, 4−6 times higher than in those without diverticular disease (24 in 2010 to 77 in 2021) (p < 0.001). Patients with diverticular disease were at higher risk for EOCRC than those without (OR: 1.76, 95% CI: 1.40−2.32). Conclusion: The incidence of EOCRC continuously increased from 2010 through 2021 in patients with and without diverticular disease and was 4−6 times higher among patients with diverticular disease. Patients with pre-existing diverticular disease were at a significantly increased risk for EOCRC.
研究2010年至2021年间患有和未患有憩室病的患者中早发性结直肠癌（EOCRC）发病率的时间趋势，并探讨憩室病是否与EOCRC风险增加相关。方法：这是一项对46179351名20至49岁的年轻成年人进行的回顾性队列研究，其中包括298117名患有憩室病的患者。我们研究了2010年至2021年间患有和未患有憩室病的患者首次诊断为EOCRC的年发病率。将已患憩室病患者中EOCRC的5年风险与倾向匹配的无憩室病和EOCRC的患者进行比较，并计算优势比（OR）和95%置信区间（CI）。结果：已患憩室病的年轻成年人中，EOCRC新诊断的年发病率（以每年每10万人中的新病例数衡量）从2010年的100增加到2021年的402，比未患憩室病的人高4至6倍（2010年为24，2021年为77）（p<0.001）。患有憩室病的患者患EOCRC的风险高于未患憩室病的患者（OR：1.76，95%CI：1.40 - 2.32）。结论：2010年至2021年间，患有和未患有憩室病的患者中EOCRC的发病率持续上升，且在患有憩室病的患者中高出4至6倍。已患憩室病的患者患EOCRC的风险显著增加。
Zotero 插件
