Section of Forensic Pathology, Department of Forensic Medicine, University of Copenhagen, 2100 Copenhagen, Denmark.
Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, 2100 Copenhagen, Denmark.
Cells. 2022 Oct 8;11(19):3160. doi: 10.3390/cells11193160.
The normal human heart contains epicardial adipose tissue (EAT) and myocardial fat. The associations between obesity, myocardial fat, visceral adipose tissue (VAT), and cardiovascular disease are not fully understood. The objective of this study was to estimate myocardial fat using stereological methods and investigate its relations with obesity, EAT, and VAT. To establish the EAT volume, 115 deceased individuals were included, and postmortem computed tomography was conducted on their eviscerated hearts. Six samples from the left and right ventricles (LV and RV) of the heart were stereologically examined to calculate the percentage of myocardial fat. Kidney and omental fat were weighed at autopsy, and the waist-hip ratio was calculated. Females had a slightly non-significantly ( = 0.054) larger proportion of RV fat (13.2% ± 4.4) compared to that in men (11.5% ± 2.7). We found a significant positive correlation between body mass index (BMI) and LV myocardial fat ( = 0.033). In the RV, this correlation was only at the borderline of significance ( = 0.052). The EAT volume was positively correlated with both RV and LV myocardial fat. We found no association with the waist-hip ratio (WHR) or the omental or kidney fat as measures of VAT. The myocardial fat was normal, most prominent in the RV, and correlated with the EAT and, partly, BMI. We found no association with VAT.
正常人的心脏包含心外膜脂肪组织 (EAT) 和心肌脂肪。肥胖、心肌脂肪、内脏脂肪组织 (VAT) 与心血管疾病之间的关系尚未完全阐明。本研究的目的是使用体视学法估计心肌脂肪，并研究其与肥胖、EAT 和 VAT 的关系。为了确定 EAT 体积，纳入了 115 名已故个体，并对其离体心脏进行了死后 CT 检查。对心脏的左心室 (LV) 和右心室 (RV) 的 6 个样本进行体视学检查，以计算心肌脂肪的百分比。在尸检时称重肾脏和网膜脂肪，并计算腰围臀围比。女性 RV 中的脂肪比例（13.2%±4.4）略高于男性（11.5%±2.7），但无统计学意义（ = 0.054）。我们发现 BMI 与 LV 心肌脂肪呈显著正相关（ = 0.033）。在 RV 中，这种相关性仅在统计学上具有边缘意义（ = 0.052）。EAT 体积与 RV 和 LV 心肌脂肪均呈正相关。我们发现与腰围臀围比（WHR）或网膜或肾脏脂肪（作为 VAT 的衡量标准）之间没有关联。心肌脂肪正常，以 RV 最为明显，与 EAT 部分相关，与 BMI 也相关，与 VAT 无关。
