Arpaci Dilek, Gurkan Tocoglu Aysel, Yilmaz Sabiye, Ergenc Hasan, Tamer Ali, Keser Nurgul, Gunduz Huseyin
Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey.
Department of Internal Medicine, Faculty of Medicine, Sakarya University Training and Research Hospital, Sakarya, Turkey.
J Ovarian Res. 2015 Nov 6;8:71. doi: 10.1186/s13048-015-0197-4.
Polycystic ovary syndrome (PCOS) is related to metabolic syndrome, insulin resistance, and cardiovascular metabolic syndromes. This is particularly true for individuals with central and abdominal obesity because visceral abdominal adipose tissue (VAAT) and epicardial adipose tissue (EAT) produce a large number of proinflammatory and proatherogenic cytokines. The present study aimed to determine whether there are changes in VAAT and EAT levels which were considered as indirect predictors for subclinical atherosclerosis in lean patients with PCOS.
The clinical and demographic characteristics of 35 patients with PCOS and 38 healthy control subjects were recorded for the present study. Additionally, the serum levels of various biochemical parameters were measured and EAT levels were assessed using 2D-transthoracic echocardiography.
There were no significant differences in mean age (p = 0.056) or mean body mass index (BMI) (p = 0.446) between the patient and control groups. However, the body fat percentage, waist-to-hip ratio, amount of abdominal subcutaneous adipose tissue, and VAAT thickness were higher in the PCOS patient group than in the control group. The amounts of EAT in the patient and control groups were similar (p = 0.384). EAT was correlated with BMI, fat mass, waist circumference, and hip circumference but not with any biochemical metabolic parameters including the homeostasis model assessment of insulin resistance index or the levels of triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein (HDL) cholesterol. However, there was a small positive correlation between the amounts of VAAT and EAT. VAAT was directly correlated with body fat parameters such as BMI, fat mass, and abdominal subcutaneous adipose thickness and inversely correlated with the HDL cholesterol level.
The present study found that increased abdominal adipose tissue in patients with PCOS was associated with atherosclerosis. Additionally, EAT may aid in the determination of the risk of atherosclerosis in patients with PCOS because it is easily measured.
多囊卵巢综合征（PCOS）与代谢综合征、胰岛素抵抗及心血管代谢综合征相关。对于伴有中心性和腹部肥胖的个体而言尤其如此，因为内脏腹部脂肪组织（VAAT）和心外膜脂肪组织（EAT）会产生大量促炎和促动脉粥样硬化细胞因子。本研究旨在确定在体型偏瘦的PCOS患者中，VAAT和EAT水平是否存在变化，这二者被视为亚临床动脉粥样硬化的间接预测指标。
本研究记录了35例PCOS患者和38例健康对照者的临床及人口统计学特征。此外，测量了各种生化参数的血清水平，并使用二维经胸超声心动图评估EAT水平。
患者组和对照组之间的平均年龄（p = 0.056）或平均体重指数（BMI）（p = 0.446）无显著差异。然而，PCOS患者组的体脂百分比、腰臀比、腹部皮下脂肪组织量和VAAT厚度均高于对照组。患者组和对照组的EAT量相似（p = 0.384）。EAT与BMI、脂肪量、腰围和臀围相关，但与任何生化代谢参数均无关联，包括胰岛素抵抗指数的稳态模型评估或甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白（HDL）胆固醇水平。然而，VAAT量与EAT量之间存在微弱的正相关。VAAT与BMI、脂肪量和腹部皮下脂肪厚度等体脂参数直接相关，与HDL胆固醇水平呈负相关。
本研究发现，PCOS患者腹部脂肪组织增加与动脉粥样硬化相关。此外，EAT可能有助于确定PCOS患者的动脉粥样硬化风险，因为其易于测量。
