Lee M
Growth. 1987 Spring;51(1):146-53.
The effect of maternal alcohol consumption on fetal growth and development during mid-gestation was investigated in Swiss white mice. As early as day 12 of gestation alcohol-exposed fetuses are retarded in both weight and length and remain retarded by about 0.5 to 1 day through day 16, when the experiment was terminated. From day 12 to day 16 alcohol-exposed fetuses were retarded in morphological development by about one half day, compared to controls not exposed to alcohol. Palate development began later in alcohol-exposed fetuses and was not complete in most fetuses until about 15 days 18 hours, whereas fusion was complete in most control fetuses by 15 days 0 hours. No evidence for an effect of uterine position on palate development was observed, either in control or alcohol-exposed fetuses. The manner in which alcohol consumption may affect fetal growth and development is discussed in light of these results.
在瑞士小白鼠身上研究了孕期中期母体饮酒对胎儿生长发育的影响。早在妊娠第12天，暴露于酒精环境下的胎儿在体重和体长方面就出现了发育迟缓，并且在实验于第16天终止时，其发育迟缓情况持续了约0.5至1天。从第12天到第16天，与未暴露于酒精环境的对照组相比，暴露于酒精环境下的胎儿在形态发育上迟缓了约半天。暴露于酒精环境下的胎儿腭部发育开始得较晚，大多数胎儿直到约15天18小时腭部发育才完成，而大多数对照胎儿在15天0小时时腭部融合就已完成。在对照胎儿或暴露于酒精环境下的胎儿中，均未观察到子宫位置对腭部发育有影响的证据。根据这些结果，讨论了饮酒可能影响胎儿生长发育的方式。
