大鼠子宫内暴露于酒精和咖啡因后的早期胚胎发育
Early embryonic development in the rat following in utero exposure to alcohol and caffeine.
作者信息
Ross C P, Persaud T V
机构信息
Department of Anatomy, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
出版信息
Histol Histopathol. 1986 Jan;1(1):13-7.
The influence of both alcohol and caffeine on early embryonic development was investigated in pregnant rats. Compared to the corresponding controls, a high incidence of resorptions and abnormal embryos was induced following treatment of the animals with alcohol (0.015 ml/g body weight, 12.5% v/v, i.p.) on gestational days 6 through 12 and with caffeine (25 mg/kg body weight, i.v.) on gestational day 10. In addition, embryonic growth was severely affected. Reduction of placental blood circulation and impairment of cellular proliferation may account for the observed deleterious effects on the embryo.
在怀孕大鼠中研究了酒精和咖啡因对早期胚胎发育的影响。与相应的对照组相比，在妊娠第6至12天用酒精（0.015 ml/g体重，12.5% v/v，腹腔注射）以及在妊娠第10天用咖啡因（25 mg/kg体重，静脉注射）处理动物后，出现了高比例的吸收胎和异常胚胎。此外，胚胎生长受到严重影响。胎盘血液循环的减少和细胞增殖的受损可能是观察到的对胚胎的有害影响的原因。
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