Faculty of Chemical Technology and Engineering, Bydgoszcz University of Science and Technology, 3 Seminaryjna Street, 85-326 Bydgoszcz, Poland.
Faculty of Chemical Technology and Engineering, West Pomeranian University of Technology in Szczecin, Piastów Ave. 42, 71-065 Szczecin, Poland.
Int J Mol Sci. 2022 Oct 3;23(19):11738. doi: 10.3390/ijms231911738.
Recently, there has been a special research focus on the bioconversion of glycerol to 1,3-propanediol (1,3-PD) due to its significance in the chemical industry. However, the treatment and separation of fermentation broths is a great challenge. Currently, the reverse osmosis (RO) process is a reliable state-of-the-art technique for separation of biological solutions. This study (as the first to do so) investigated the feasibility of separation of 1,3-PD broths with the use of cellulose acetate (CA) membrane by the RO process. The experiments were carried out using the installation equipped with the plate module, under the transmembrane pressure (TMP) and temperature of 1 MPa and 298 K, respectively. It was found that the used membrane was suitable for broth separation. Indeed, it was noted that 1,3-PD, as a target product, migrated through the membrane; meanwhile, other broth components were rejected in various degrees. Moreover, it was proven that retention of carboxylic acids tended to increase with increasing molecular weight, according to the following order: succinic acid > lactic acid > acetic acid > formic acid. With regards to ions, retention degree increased with the increase of ionic radius and decrease of diffusion coefficient. Finally, it was demonstrated that the CA membrane is resistant to irreversible fouling, which has a positive effect on the economic viability of the process.
最近，由于甘油在化学工业中的重要性，人们对甘油到 1,3-丙二醇（1,3-PD）的生物转化特别关注。然而，发酵液的处理和分离是一个巨大的挑战。目前，反渗透（RO）工艺是一种用于分离生物溶液的可靠的先进技术。本研究（首次进行了这项研究）考察了使用 RO 工艺通过醋酸纤维素（CA）膜分离 1,3-PD 发酵液的可行性。实验在配备有板模块的装置中进行，跨膜压力（TMP）和温度分别为 1 MPa 和 298 K。结果表明，所使用的膜适合于发酵液的分离。实际上，已经注意到作为目标产物的 1,3-PD 通过膜迁移；同时，其他发酵液成分被不同程度地排斥。此外，事实证明，根据以下顺序，羧酸的保留率随着分子量的增加而增加：琥珀酸>乳酸>乙酸>甲酸。对于离子，保留程度随离子半径的增加和扩散系数的减小而增加。最后，证明 CA 膜耐不可逆污染，这对该过程的经济可行性有积极影响。
Zotero 插件
