Department of Pathophysiology, Medical College, Nanchang University, 461 Bayi Road, Nanchang 330006, China.
Second Clinical Medical College, Nanchang University, Nanchang 330006, China.
Int J Mol Sci. 2022 Oct 4;23(19):11755. doi: 10.3390/ijms231911755.
In recent years, malignant breast cancer metastasis has caused a great increase in mortality. Research on the genetic and molecular mechanisms of malignant breast cancer has continued to deepen, and targeted therapy has become the general trend. Among them, competing endogenous RNA (ceRNA)-related molecules have received much attention. Homeobox transcript antisense RNA ) has been reported to function extensively as a ceRNA in breast cancer. Notably, and ( have also been found to play a role in breast cancer. However, the relationship between the three remains unclear. In this study, we present a new mechanic through bioinformatics tool and basic experiments: the // axis, which complemented the role network of as a ceRNA, thus, it will provide a novel potential idea for breast cancer research and therapy.
近年来，恶性乳腺癌转移导致死亡率大大增加。恶性乳腺癌的遗传和分子机制的研究不断深入，靶向治疗已成为大势所趋。其中，竞争内源性 RNA（ceRNA）相关分子受到广泛关注。同源盒转录反义 RNA（HOXA-AS1）已被报道在乳腺癌中广泛发挥 ceRNA 的作用。值得注意的是，HOXA-AS2 和 HOXA-AS3 也被发现与乳腺癌有关。然而，这三者之间的关系尚不清楚。在这项研究中，我们通过生物信息学工具和基础实验提出了一种新的机制：// 轴，补充了作为 ceRNA 的 HOXA-AS1 的作用网络，因此，它将为乳腺癌的研究和治疗提供新的潜在思路。
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