铁死亡及铁死亡相关长非编码 RNA 在乳腺癌中的作用。
Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer.
机构信息
Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, 421001, Hunan, China.
出版信息
Cell Mol Biol Lett. 2024 Mar 26;29(1):40. doi: 10.1186/s11658-024-00560-2.
Ferroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and reactive oxygen species (ROS) metabolism, including the X/GSH/GPX4 system, ACSL4/LPCAT3/15-LOX and FSP1/CoQ10/NAD(P)H pathways, and investigate the correlation between ferroptosis and LncRNA in BC to determine possible biomarkers related to ferroptosis.
铁死亡是一种治疗肿瘤的策略，是一种受调控的细胞死亡形式，其特征是铁依赖性脂质过氧化物 (LPO) 的积累增加。肿瘤相关的长非编码 RNA (lncRNA) 与传统抗癌药物或放射治疗相结合，可以提高癌症的疗效并降低死亡率。研究铁死亡相关 lncRNA 的作用可能有助于为乳腺癌 (BC) 制定新的治疗方案。在这里，我们简要讨论了涉及铁和活性氧 (ROS) 代谢的铁死亡相关基因和途径，包括 X/GSH/GPX4 系统、ACSL4/LPCAT3/15-LOX 和 FSP1/CoQ10/NAD(P)H 途径，并研究了铁死亡与 BC 中 LncRNA 之间的相关性，以确定与铁死亡相关的可能生物标志物。
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