Liu Wenhui, Jiang Chenjun, Ma Yun, Wang Wentao, Peng Jing, Ma Weiqing, Xu Shuxin, Wu Duoming
The First Clinical Medical College, Lanzhou University, Lanzhou, China.
Department of Breast Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Front Cell Dev Biol. 2024 Dec 23;12:1506492. doi: 10.3389/fcell.2024.1506492. eCollection 2024.
Ferroptosis, distinct from apoptosis, is primarily characterized by the accumulation of iron-dependent lipid peroxides (LPO) and reactive oxygen species (ROS). This process plays a pivotal role in the pathophysiology of various diseases and has recently emerged as a promising therapeutic strategy in oncology, garnering significant attention. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), serve as crucial regulators in numerous biological processes, particularly in cancer initiation and progression. Increasing research efforts are focused on targeting ferroptosis through modulation of these ncRNAs. This review provides an overview of the mechanisms underlying ferroptosis and explores the roles of ncRNAs in breast cancer (BC) and its regulation. Furthermore, we examine the interactions between ferroptosis and ncRNAs in BC, aiming to identify potential therapeutic targets for BC treatment.
铁死亡不同于细胞凋亡，其主要特征是铁依赖性脂质过氧化物（LPO）和活性氧（ROS）的积累。这一过程在多种疾病的病理生理学中起关键作用，最近已成为肿瘤学中一种有前景的治疗策略，备受关注。非编码RNA（ncRNA），包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA），在众多生物学过程中发挥着关键调节作用，尤其是在癌症的发生和发展过程中。越来越多的研究致力于通过调控这些ncRNA来靶向铁死亡。本文综述了铁死亡的潜在机制，并探讨了ncRNA在乳腺癌（BC）中的作用及其调控。此外，我们研究了BC中铁死亡与ncRNA之间的相互作用，旨在确定BC治疗的潜在靶点。
