Jackson G M, Hall D E, Walker R
Food Chem Toxicol. 1987 Jul;25(7):505-13. doi: 10.1016/0278-6915(87)90201-8.
The short-term effects of citral on the liver have been studied in two strains of rat. Hepatomegaly was accompanied in citral-treated rats by an altered distribution of lipid and glycogen in the liver and peroxisome proliferation occurred in a manner reminiscent of that associated with some hypolipidaemic compounds. Specific biochemical markers supported the morphological changes in the peroxisomes. Cyanide-insensitive palmitoyl CoA oxidation showed, at the maximum, fourfold and threefold inductions in Wistar albino and Long Evans hooded rats, respectively. In addition, induction of cytochrome P-450 levels was greater in the Long Evans than in the Wistar rats, the maximal increases recorded being 81 and 27% respectively. A peroxisome-associated polypeptide of molecular weight 80,000 daltons (PPA-80) was induced, especially in Long Evans rats. No alterations in plasma triglycerides or total cholesterol were detected. The differential induction of the mixed-function oxidase system and the differential proliferation of peroxisomes in these two strains of rat suggest that citral may be metabolized differently in the two strains. The study indicates that peroxisomal and possibly also mitochondrial changes are involved in the action of citral on lipid metabolism.
已在两种品系的大鼠中研究了柠檬醛对肝脏的短期影响。柠檬醛处理的大鼠出现肝脏肿大，同时肝脏中脂质和糖原的分布发生改变，并且过氧化物酶体增殖的发生方式类似于某些降血脂化合物相关的情况。特定的生化标志物支持了过氧化物酶体的形态变化。对氰化物不敏感的棕榈酰辅酶A氧化在Wistar白化大鼠和Long Evans带帽大鼠中分别最多有四倍和三倍的诱导。此外，Long Evans大鼠中细胞色素P-450水平的诱导高于Wistar大鼠，记录到的最大增加分别为81%和27%。诱导出一种分子量为80,000道尔顿的过氧化物酶体相关多肽（PPA-80），尤其是在Long Evans大鼠中。未检测到血浆甘油三酯或总胆固醇的变化。这两种品系大鼠中混合功能氧化酶系统的差异诱导和过氧化物酶体的差异增殖表明，柠檬醛在这两种品系中的代谢可能不同。该研究表明，过氧化物酶体以及可能还有线粒体的变化参与了柠檬醛对脂质代谢的作用。
