Elson C E, Underbakke G L, Hanson P, Shrago E, Wainberg R H, Qureshi A A
Department of Nutritional Sciences, University of Wisconsin, Madison 53706.
Lipids. 1989 Aug;24(8):677-9. doi: 10.1007/BF02535203.
To test the hypothesis that non-sterol mevalonate pathway end products lower serum cholesterol levels, we asked 22 hypercholesterolemic subjects (315 +/- 9 mg cholesterol/dl) to take a daily capsule containing 140 mg of lemongrass oil, an essential oil rich in geraniol and citral. The paired difference in serum cholesterol levels of subjects completing the 90-day study approached significance (P less than 0.06, 2-tailed t-test). The subjects segregated into two groups, one consisting of 14 subjects resistant to the protocol and the other consisting of 8 subjects who responded. Paired differences in cholesterol level at 30, 60 and 90 d for resistant subjects were +2 +/- 6, +2 +/- 7 and -1 +/- 6 mg/dl; paired differences for the responding subjects were -25 +/- 10 (p less than 0.05), -33 +/- 8 (p less than 0.01) and -38 +/- 10 (p less than 0.025), respectively. The paired difference (+8 +/- 4) in the cholesterol levels of six responders 90 days after the discontinuation of lemongrass oil was not significant.
为了验证非甾醇甲羟戊酸途径终产物可降低血清胆固醇水平这一假设，我们让22名高胆固醇血症患者（血清胆固醇水平为315±9mg/dl）每日服用一粒含有140mg柠檬草油的胶囊，柠檬草油是一种富含香叶醇和柠檬醛的香精油。完成90天研究的受试者血清胆固醇水平的配对差异接近显著水平（双侧t检验，P<0.06）。受试者分为两组，一组由14名对该方案无反应的受试者组成，另一组由8名有反应的受试者组成。无反应受试者在30天、60天和90天时胆固醇水平的配对差异分别为+2±6、+2±7和-1±6mg/dl；有反应受试者的配对差异分别为-25±10（P<0.05）、-33±8（P<0.01）和-38±10（P<0.025）。停用柠檬草油90天后，6名有反应者的胆固醇水平配对差异（+8±4）不显著。
