Miao Zhuangzhuang, Wang Huajian, Cai Zhi, Lei Jin, Wan Xueyan, Li Yu, Wang Junwen, Zhao Kai, Niu Hongquan, Lei Ting
Department of Neurosurgery, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan 430030, China.
Department of Neurosurgery, Wuhan Fourth Hospital, Puai Hospital, Wuhan 430030, China.
J Clin Med. 2022 Sep 22;11(19):5564. doi: 10.3390/jcm11195564.
The spontaneous hyperventilation (SHV) accompanying spontaneous cerebellar hemorrhage has yet to attract a sufficient amount of attention. This study aimed to analyze the incidence of SHV in spontaneous cerebellar hemorrhage patients and its risk factors as well as its association with the outcome.
We retrospectively reviewed the medical records of all spontaneous cerebellar hemorrhage patients who underwent surgical treatment at Tongji Hospital from July 2018 to December 2020. Arterial blood gas (ABG) test results and clinical characteristics, including demographics, comorbidities, imaging features, laboratory tests, and therapy choices, were collected. The Glasgow Outcome Scale was used to assess the outcome at two weeks and six months after admission.
A total of 147 patients were included, and of these patients 44.9% had spontaneous hyperventilation. Hypertension (OR, 3.175; CI, 1.332-7.569), usage of sedation drugs (OR, 3.693; CI, 1.0563-8.724), and hypernatremia (OR, 2.803; CI, 1.070-7.340) seemed to positively correlate to SHV occurrence. Hematoma removal had an inverse association with SHV (OR, 0.176; CI, 0.068-0.460). Patients with poor and good outcomes had significant differences in pH, PaCO, and HCO values, and the severity of SHV was associated with the PaCO level.
Spontaneous hyperventilation is common in patients with spontaneous cerebellar hemorrhage, and its severity is associated with the outcome.
自发性小脑出血伴随的自发性过度通气（SHV）尚未引起足够的关注。本研究旨在分析自发性小脑出血患者中SHV的发生率及其危险因素，以及其与预后的关系。
我们回顾性分析了2018年7月至2020年12月在同济医院接受手术治疗的所有自发性小脑出血患者的病历。收集动脉血气（ABG）检测结果和临床特征，包括人口统计学、合并症、影像学特征、实验室检查和治疗选择。采用格拉斯哥预后量表评估入院后两周和六个月的预后。
共纳入147例患者，其中44.9%的患者出现自发性过度通气。高血压（OR，3.175；CI，1.332 - 7.569）、使用镇静药物（OR，3.693；CI，1.0563 - 8.724）和高钠血症（OR，2.803；CI，1.070 - 7.340）似乎与SHV的发生呈正相关。血肿清除与SHV呈负相关（OR，0.176；CI，0.068 - 0.460）。预后良好和不良的患者在pH、PaCO和HCO值方面存在显著差异，且SHV的严重程度与PaCO水平相关。
自发性过度通气在自发性小脑出血患者中很常见，其严重程度与预后相关。
