Departments of Pediatrics and Medicine, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71103, USA.
Nutrients. 2022 Sep 20;14(19):3893. doi: 10.3390/nu14193893.
Population studies have shown a trend in decreasing vitamin C status and increasing prevalence of osteoporosis in patients with diabetes and non-diabetic people. Dietary vitamin C consumption is linked to improvement in bone mineral density (BMD) in epidemiological studies. VCAM-1 and adiponectin are known to activate osteoclasts, which increase bone loss.
This study examined whether there is any association between the circulating level of vitamin C and BMD and whether the beneficial effect of vitamin C on BMD was linked to a simultaneous decrease in circulating levels of adiponectin and VCAM-1 in subjects with diabetes.
Patients with diabetes (T2D, = 74) and age-matched non-diabetic controls ( = 26) were enrolled in this study. Fasting blood levels of glycemia, adiponectin, VCAM-1, inflammation biomarkers, and vitamin C were determined in both groups. The BMD of the lumbar spine (L1-L4), left femur, and right femur was determined using a DXA scan in subjects with diabetes.
Patients with diabetes had lower levels of vitamin C and higher levels of VCAM-1 and inflammatory cytokines. There was a significant positive association between vitamin C blood levels and lumbar spine BMD as well as a significant negative association between total adiponectin and VCAM-1 levels with that of vitamin C and lumbar BMD in patients with diabetes. Total adiponectin and VCAM-1 also showed a negative association with BMD of both the right and left femurs. The inter-relationship among the circulating levels of vitamin C and VCAM-1 and BMD was strong and is a novel finding.
This study reports a positive association of circulating vitamin C levels and the BMD and that the beneficial effects of vitamin C on BMD could be linked to a simultaneous lowering in circulating VCAM-1 and total adiponectin levels. Thus, dietary vitamin C consumption has potential to lower inflammation and the risk of osteoporosis in subjects with diabetes.
人群研究表明，糖尿病患者和非糖尿病患者的维生素 C 状态呈下降趋势，骨质疏松症的患病率呈上升趋势。饮食中维生素 C 的摄入与流行病学研究中骨密度（BMD）的改善有关。已知 VCAM-1 和脂联素可激活破骨细胞，从而增加骨质流失。
本研究旨在探讨糖尿病患者循环维生素 C 水平与 BMD 之间是否存在相关性，以及维生素 C 对 BMD 的有益作用是否与同时降低循环脂联素和 VCAM-1 水平有关。
本研究纳入了 74 例糖尿病患者（T2D）和 26 例年龄匹配的非糖尿病对照者。两组均测定空腹血糖、脂联素、VCAM-1、炎症标志物和维生素 C 水平。对糖尿病患者进行腰椎（L1-L4）、左侧股骨和右侧股骨的 DXA 扫描，以确定 BMD。
糖尿病患者的维生素 C 水平较低，VCAM-1 和炎症细胞因子水平较高。糖尿病患者的维生素 C 血水平与腰椎 BMD 呈显著正相关，而总脂联素和 VCAM-1 水平与维生素 C 和腰椎 BMD 呈显著负相关。总脂联素和 VCAM-1 与右侧和左侧股骨的 BMD 也呈负相关。循环维生素 C 与 VCAM-1 和 BMD 之间的相互关系很强，这是一个新的发现。
本研究报告了循环维生素 C 水平与 BMD 呈正相关，维生素 C 对 BMD 的有益作用可能与同时降低循环 VCAM-1 和总脂联素水平有关。因此，饮食中维生素 C 的摄入有可能降低糖尿病患者的炎症和骨质疏松症风险。
