Sela O, el-Roeiy A, Pick A I, Shoenfeld Y
Immunol Lett. 1987 Jun;15(2):117-20. doi: 10.1016/0165-2478(87)90041-1.
Serum immunoglobulins levels were determined in 42 patients with active pulmonary tuberculosis as a prototype of chronic infection and 41 patients with Klebsiella infection representing acute infection, using a radial immunodiffusion technique. The mean serum concentration of IgG, IgA and IgM of the patients with pulmonary tuberculosis (1980 +/- 688, 314 +/- 152 and 222 +/- 123 mg/dl, respectively) were found to be significantly higher than normal control levels (P less than 0.005). The mean serum IgG, IgA and IgM concentration of the patients with Klebsiella infection (1102 +/- 340, 287 +/- 133 and 168 +/- 105 mg/dl, respectively), were also higher than normal levels but only IgM level differed significantly from the normal control levels (P less than 0.05). The difference in serum IgG and IgM between the patients with pulmonary tuberculosis and Klebsiella infection was statistically significant (P less than 0.05 and P less than 0.05, respectively). These findings reflect the polyclonal hypergammaglobulinemia found in chronic infections, on the one hand, and the rise of IgM of the primary immune response in acute infection, on the other.
采用放射免疫扩散技术，对42例活动性肺结核患者（作为慢性感染的典型病例）和41例克雷伯菌感染患者（代表急性感染）的血清免疫球蛋白水平进行了测定。结果发现，肺结核患者的血清IgG、IgA和IgM平均浓度（分别为1980±688、314±152和222±123mg/dl）显著高于正常对照水平（P＜0.005）。克雷伯菌感染患者的血清IgG、IgA和IgM平均浓度（分别为1102±340、287±133和168±105mg/dl）也高于正常水平，但只有IgM水平与正常对照水平有显著差异（P＜0.05）。肺结核患者和克雷伯菌感染患者之间血清IgG和IgM的差异具有统计学意义（分别为P＜0.05和P＜0.05）。这些发现一方面反映了慢性感染中出现的多克隆高丙种球蛋白血症，另一方面反映了急性感染中初级免疫反应的IgM升高。
