Lu Qian, Wang Yang-Yang, Chen Hui-Min, Wang Qiu-Hong, Yang Xiao-Yan, Zou Li-Ping
Senior Department of Pediatrics, Chinese PLA General Hospital, Beijing, China.
Department of Pediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Front Neurol. 2022 Sep 27;13:982050. doi: 10.3389/fneur.2022.982050. eCollection 2022.
, encoding the alpha 1 subunit of the sodium channel, is associated with a range of related epilepsy. This study aims to assess saliva and urine pH in children with -related epilepsy.
A prospective controlled observational study with a 1:1 ratio was conducted on seven patients with -related epilepsy and seven healthy children of the same family, gender, and age but without a history of seizures. The pH of saliva and urine was measured by pH test paper. Parents of patients with epilepsy recorded seizures to compare the relationship between pH and seizures.
The fourteen participants were all males, aged 1 to 14 years. Seven patients had different pathogenic variants. The pH of saliva and urine was monitored for 21-95 days. The pH of saliva and urine was higher in patients with -related epilepsy than in the healthy group. The urine pH in Dravet syndrome patients was high compared with other epilepsy patients. The urine pH in patients with seizures was higher than that in patients without seizures, which occurred during the study.
The pH of saliva and urine was chronically high in patients with -related epilepsy, and urine pH was higher in patients with seizures and with Dravet syndrome.
编码钠通道α1亚基的[相关基因名称未给出]与一系列相关癫痫有关。本研究旨在评估[相关基因名称未给出]相关癫痫患儿的唾液和尿液pH值。
对7例[相关基因名称未给出]相关癫痫患儿和7名来自同一家族、性别和年龄相同但无癫痫发作史的健康儿童进行了1:1比例的前瞻性对照观察研究。用pH试纸测量唾液和尿液的pH值。癫痫患儿的家长记录癫痫发作情况，以比较pH值与癫痫发作之间的关系。
14名参与者均为男性，年龄在1至14岁之间。7例患者有不同的致病[相关基因名称未给出]变异。对唾液和尿液的pH值进行了21 - 95天的监测。[相关基因名称未给出]相关癫痫患者的唾液和尿液pH值高于健康组。与其他癫痫患者相比，Dravet综合征患者的尿液pH值较高。在研究期间，癫痫发作患者的尿液pH值高于无癫痫发作患者。
[相关基因名称未给出]相关癫痫患者的唾液和尿液pH值长期偏高，癫痫发作患者和Dravet综合征患者的尿液pH值更高。
