Jangda Anzal, Voloshyna Diana, Ramesh Krishna, Bseiso Anan, Shaik Tanveer Ahamad, Al Barznji Saman, Usama Muhammad, Saleem Faraz, Ghaffari Muhammad Abu Zar
Internal Medicine, Ziauddin University, Karachi, PAK.
School of Medicine, University of Michigan, Ann Arbor, USA.
Cureus. 2022 Sep 10;14(9):e29008. doi: 10.7759/cureus.29008. eCollection 2022 Sep.
The presentation of vitamin B12 deficiency varies from being asymptomatic to affecting multiple organ systems. In addition, several systemic diseases can be associated with generalized weakness and hyperpigmentation. However, vitamin B12 deficiency rarely presents with hyperpigmentation as an initial symptom. We present a rare case of a 22-year-old college student who presented with hyperpigmentation as the only physical manifestation of early vitamin B12 deficiency. This case underlines the need to rule out vitamin B12 deficiency when clinicians encounter hyperpigmentation as a solo presentation and also emphasizes the significance of early treatment in preventing the irreversible neurological manifestations of vitamin B12 deficiency.
维生素B12缺乏的表现各不相同，从无症状到影响多个器官系统。此外，几种全身性疾病可能与全身无力和色素沉着有关。然而，维生素B12缺乏很少以色素沉着作为初始症状出现。我们报告一例罕见病例，一名22岁的大学生，色素沉着是早期维生素B12缺乏的唯一身体表现。该病例强调，当临床医生遇到单独出现的色素沉着时，需要排除维生素B12缺乏，同时也强调了早期治疗对预防维生素B12缺乏不可逆神经表现的重要性。
