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蒽环类药物所致心脏毒性的心脏磁共振成像评估

Cardiac MRI assessment of anthracycline-induced cardiotoxicity.

作者信息

Mabudian Leila, Jordan Jennifer H, Bottinor Wendy, Hundley W Gregory

机构信息

Division of Cardiology, Department of Internal Medicine, VCU School of Medicine, Richmond, VA, United States.

Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, United States.

出版信息

Front Cardiovasc Med. 2022 Sep 27;9:903719. doi: 10.3389/fcvm.2022.903719. eCollection 2022.

DOI:10.3389/fcvm.2022.903719
PMID:36237899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9551168/
Abstract

The objective of this review article is to discuss how cardiovascular magnetic resonance (CMR) imaging measures left ventricular (LV) function, characterizes tissue, and identifies myocardial fibrosis in patients receiving anthracycline-based chemotherapy (Anth-bC). Specifically, CMR can measure LV ejection fraction (EF), volumes at end-diastole (LVEDV), and end-systole (LVESV), LV strain, and LV mass. Tissue characterization is accomplished through T1/T2-mapping, late gadolinium enhancement (LGE), and CMR perfusion imaging. Despite CMR's accuracy and efficiency in collecting data about the myocardium, there are challenges that persist while monitoring a cardio-oncology patient undergoing Anth-bC, such as the presence of other cardiovascular risk factors and utility controversies. Furthermore, CMR can be a useful adjunct during cardiopulmonary exercise testing to pinpoint cardiovascular mediated exercise limitations, as well as to assess myocardial microcirculatory damage in patients undergoing Anth-bC.

摘要

这篇综述文章的目的是讨论心血管磁共振成像（CMR）如何测量接受蒽环类药物化疗（Anth-bC）患者的左心室（LV）功能、对组织进行特征描述以及识别心肌纤维化。具体而言，CMR可以测量左心室射血分数（EF）、舒张末期容积（LVEDV）、收缩末期容积（LVESV）、左心室应变和左心室质量。组织特征描述通过T1/T2映射、延迟钆增强（LGE）和CMR灌注成像来完成。尽管CMR在收集有关心肌的数据方面具有准确性和高效性，但在监测接受Anth-bC的心脏肿瘤患者时仍存在挑战，例如存在其他心血管危险因素和效用争议。此外，CMR在心肺运动测试期间可能是一种有用的辅助手段，以确定心血管介导的运动限制，以及评估接受Anth-bC患者的心肌微循环损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/3784369a9de0/fcvm-09-903719-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/adf0aa8d929c/fcvm-09-903719-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/bd99128bb72d/fcvm-09-903719-g009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/3784369a9de0/fcvm-09-903719-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/f283f4ceb694/fcvm-09-903719-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/0ae3cef7aa55/fcvm-09-903719-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/adf0aa8d929c/fcvm-09-903719-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/bd99128bb72d/fcvm-09-903719-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/3b0354f162b1/fcvm-09-903719-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/3372a038375a/fcvm-09-903719-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbe6/9551168/3784369a9de0/fcvm-09-903719-g013.jpg

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