Romo-González Tania, Barranca-Enríquez Antonia, León-Díaz Rosalba, Del Callejo-Canal Enrique, Gutiérrez-Ospina Gabriel, Jimenez Urrego Angela María, Bolaños Cristina, Botero Carvajal Alejandro
Biology and Integral Health Area of the Biological Research Institute of the Universidad Veracruzana. Dr. Luis Castelazo Ayala S/N, Industrial Animas, Rubí Animas, C.P. 91190, Xalapa-Enríquez, Veracruz, Mexico.
Center for Health Studies and Services, in the Universidad Veracruzana at Veracruz, Veracruz, Mexico.
Heliyon. 2022 Oct 7;8(10):e10883. doi: 10.1016/j.heliyon.2022.e10883. eCollection 2022 Oct.
Breast cancer (BC) is a leading cause of women's morbimortality worldwide. Unfortunately, attempts to predict women's susceptibility to developing BC well before it becomes symptomatic, based on their genetic, family, and reproductive background have proved unsatisfactory. Here we analyze the matching of personality traits and protein serum profiles to predict women's susceptibility to developing cancer. We conducted a prospective study among 150 women (aged 18-70 years), who were distributed into three groups (n = 50): women without breast pathology and women diagnosed with BC or benign breast pathology. Psychological data were obtained through standardized psychological tests and serum protein samples were analyzed through semiquantitative protein immunoblotting. The matching for psychological and immunological profiles was constructed from these data using a mathematical generalized linear model.The model predicted that women who have stronger associations between high-intensity stress responses, emotional containment, and an increased number and reduced variability of serum proteins (detected by IgG autoantibodies) have the greatest susceptibility to develop BC before the disease has manifested clinically. Hence, the present study endorses the possibility of using psychological and biochemical tests in combination to increase the possibility of identifying women at risk of developing BC before the disease shows clinical manifestations. A longitudinal study must be instrumented to test the prediction ability of the instrument in real scenarios.
Committee of Ethical Research of the Hospital General de México "Dr. Eduardo Liceaga," Ministry of Health (DI/12/111/03/064).
乳腺癌（BC）是全球女性发病和死亡的主要原因。不幸的是，基于女性的遗传、家族和生殖背景，在乳腺癌出现症状之前很久就试图预测其易感性的尝试并不令人满意。在此，我们分析人格特质与血清蛋白谱的匹配情况，以预测女性患癌的易感性。我们对150名年龄在18至70岁之间的女性进行了一项前瞻性研究，她们被分为三组（每组n = 50）：无乳腺病变的女性、被诊断为乳腺癌或乳腺良性病变的女性。通过标准化心理测试获取心理数据，并通过半定量蛋白质免疫印迹分析血清蛋白样本。利用数学广义线性模型从这些数据构建心理和免疫谱的匹配情况。该模型预测，在疾病临床显现之前，那些在高强度应激反应、情绪抑制与血清蛋白数量增加及变异性降低（通过IgG自身抗体检测）之间具有更强关联的女性患乳腺癌的易感性最高。因此，本研究支持联合使用心理和生化测试以增加在疾病出现临床表现之前识别有患乳腺癌风险女性的可能性。必须开展一项纵向研究以在实际场景中测试该检测方法的预测能力。
墨西哥城总医院“爱德华多·利塞加博士”伦理研究委员会，卫生部（DI/12/111/03/064）。
