Reinus W R, Nadel S
Invest Radiol. 1987 Jun;22(6):484-9. doi: 10.1097/00004424-198706000-00007.
Single-energy CT for bone-mineral determination underestimates the degree of mineralization because of error caused by fat in the marrow space. A correction using set theory and threshold analysis was developed to reduce this error. Corrections between 4.7% and 130.9% of fat-induced error are observed. The amount of correction is related directly to the amount of osteopenia present, and is patient specific. This technique may be appropriate for clinical evaluation because the major application of quantitative CT (QCT) is for bone mineral analysis in a population with increasing marrow space fat over time. This technique may allow reduction of the uncertainty of normal data developed using single energy QCT, thereby making the technique more sensitive to early detection of osteopenia.
用于骨矿物质测定的单能量CT由于骨髓腔内脂肪导致的误差而低估了矿化程度。开发了一种使用集合论和阈值分析的校正方法来减少这种误差。观察到校正幅度在脂肪诱导误差的4.7%至130.9%之间。校正量与存在的骨质减少量直接相关，且因患者而异。这项技术可能适用于临床评估，因为定量CT（QCT）的主要应用是针对随着时间推移骨髓腔脂肪增加的人群进行骨矿物质分析。这项技术可能会降低使用单能量QCT得出的正常数据的不确定性，从而使该技术对骨质减少的早期检测更敏感。
