Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Department of Pediatrics, Taipei Medical University Hospital, Taipei, Taiwan.
J Dev Orig Health Dis. 2023 Apr;14(2):272-278. doi: 10.1017/S2040174422000575. Epub 2022 Oct 14.
Fetal growth restriction (FGR) is associated with reduced cardiac function in neonates. Uteroplacental insufficiency (UPI) is the most common cause of FGR. The mechanisms underlying these alterations remain unknown. We hypothesized that UPI would influence cardiac development in offspring rats. Through this study, we evaluated the effects of UPI during pregnancy on heart histology and pulmonary hypertension in growth-restricted newborn rats. On gestation Day 18, either UPI was induced through bilateral uterine vessel ligation (FGR group) or sham surgery (control group) was performed. The right middle lobe of the lung and the heart were harvested for histological and immunohistochemical evaluation on postnatal days 0 and 7. The FGR group exhibited significantly lower body weight, hypertrophy and degeneration of cardiomyocytes, increased intercellular spaces between the cardiomyocytes and collagen deposition, and decreased glycogen deposition and HNK-1 expression compared with the control group on postnatal days 0 and 7. These results suggest that neonates with FGR may have inadequate myocardial reserves, which may cause subsequent cardiovascular compromise in future life. Further studies are required to evaluate the hemodynamic changes in these growth-restricted neonates.
胎儿生长受限（FGR）与新生儿心功能降低有关。胎盘功能不全（UPI）是 FGR 的最常见原因。这些变化的机制尚不清楚。我们假设 UPI 会影响后代大鼠的心脏发育。通过这项研究，我们评估了妊娠期间 UPI 对生长受限的新生大鼠心脏组织学和肺动脉高压的影响。在妊娠第 18 天，通过双侧子宫血管结扎（FGR 组）或假手术（对照组）诱导 UPI。在出生后第 0 天和第 7 天，采集右中叶肺和心脏进行组织学和免疫组织化学评估。与对照组相比，FGR 组在出生后第 0 天和第 7 天体重明显较低，心肌细胞肥大和退化，细胞间空间增大，胶原沉积增加，糖原沉积和 HNK-1 表达减少。这些结果表明，患有 FGR 的新生儿可能心肌储备不足，这可能导致未来生活中心血管功能受损。需要进一步研究来评估这些生长受限新生儿的血流动力学变化。
