CYP1A2-163C>A 多态性对咖啡因补充后运动止血反应的影响。
The influence of the CYP1A2-163 C>A polymorphism on the hemostatic response to exercise following caffeine supplementation.
机构信息
Department of Kinesiology, Human Performance Laboratory, James Madison University, Harrisonburg, VA, USA.
Integrative Exercise Physiology Laboratory, Ball State University, Muncie, IN, USA.
出版信息
J Sports Med Phys Fitness. 2023 Mar;63(3):471-477. doi: 10.23736/S0022-4707.22.14323-9. Epub 2022 Oct 14.
BACKGROUND
Prior work from our group suggests that caffeine increases thrombotic potential after acute exercise. The aim of this study was to determine if hemostatic responses to exercise affected by caffeine are influenced by the CYP1A2-163 C>A polymorphism.
METHODS
Forty-two healthy men performed two trials in which a graded maximal exercise test was completed one hour after consuming either 6 mg/kg of caffeine or placebo. Subjects were categorized as possessing the C allele (N.=21) or being homozygous for the A allele (N.=21).
RESULTS
Factor VIII increased more (265%) during exercise in the caffeinated condition than the placebo condition (178%) (P<0.05). Tissue plasminogen activator (tPA) activity also increased more following caffeine as compared to placebo (increase of 8.70±4.32 IU/mL vs. 6.77±3.79 IU/mL respectively, P<0.05). There was no treatment × genotype or treatment × time × genotype interactions.
CONCLUSIONS
Although caffeine increases factor VIII and tPA responses to maximal exercise, these changes are not influenced by the CYP1A2-163 C>A polymorphism.
背景
我们小组之前的研究表明，咖啡因会增加急性运动后的血栓形成倾向。本研究旨在确定咖啡因对运动引起的止血反应的影响是否受 CYP1A2-163 C>A 多态性的影响。
方法
42 名健康男性进行了两项试验，一项是在摄入 6mg/kg 咖啡因或安慰剂后一小时进行的分级最大运动测试，另一项是在摄入 6mg/kg 咖啡因或安慰剂后一小时进行的分级最大运动测试。受试者被分为携带 C 等位基因（N=21）或纯合 A 等位基因（N=21）。
结果
与安慰剂相比，咖啡因组在运动过程中因子 VIII 的增加更多（265%）（P<0.05）。与安慰剂相比，咖啡因组组织型纤溶酶原激活物（tPA）的活性增加更多（增加 8.70±4.32IU/mL 与 6.77±3.79IU/mL 相比，P<0.05）。没有治疗×基因型或治疗×时间×基因型的相互作用。
结论
虽然咖啡因会增加因子 VIII 和 tPA 对最大运动的反应，但这些变化不受 CYP1A2-163 C>A 多态性的影响。
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