Giatromanolaki Alexandra, Chatzipantelis Paschalis, Contrafouris Constantinos A, Koukourakis Michael I
Department of Pathology, University Hospital of Alexandroupolis, Democritus University of Thrace, Greece.
1st Cardiac Surgery Department, Onassis Cardiac Surgery Center, Athens, Greece.
Cancer Invest. 2023 Jan;41(1):48-57. doi: 10.1080/07357907.2022.2136684. Epub 2022 Nov 2.
We assessed the presence of 'tertiary lymphoid structures' (TLS) in a series of surgically treated non-small cell lung carcinomas (NSCLC). The TLS-density in the tumor periphery (pTLS) ranged from 0 to 1.8 (median 0.45), while in inner tumor areas (iTLS) ranged from 0 to 1.0 (median 0); ( < 0.0001). High pTLS-density was linked with early stage of the disease. Glycolysis-related enzyme expression (MCT1, Hexokinase 2) was linked with high pTLS-density ( < 0.05). High pTLS and iTLS densities were linked with better postoperative prognosis ( = 0.02 and = 0.01, respectively). Assessment of TLS is a useful prognostic marker in NSCLC.
我们评估了一系列手术治疗的非小细胞肺癌（NSCLC）中“三级淋巴结构”（TLS）的存在情况。肿瘤周边的TLS密度（pTLS）范围为0至1.8（中位数0.45），而肿瘤内部区域的TLS密度（iTLS）范围为0至1.0（中位数0）；（P<0.0001）。高pTLS密度与疾病的早期阶段相关。糖酵解相关酶表达（MCT1、己糖激酶2）与高pTLS密度相关（P<0.05）。高pTLS和iTLS密度与更好的术后预后相关（分别为P = 0.02和P = 0.01）。TLS评估是NSCLC中一种有用的预后标志物。
